Patients with Familial Hypobetalipoproteinemia (FHBL) could have increased hepatic glucose production because of hepatic steatosis. Additionally, peripheral insulin sensitivity could be enhanced since these patients have lower concentrations of…
ID
Bron
Verkorte titel
Aandoening
-patients with FHBL and liver steatosis
-healthy controls matched for age, BMI, waist circumference and physical activity
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
1. Insulin sensitivity at the level of glucose production by liver, glucose uptake by muscle+fat and lipolysis; <br>
2. Fat distribution by a DEXA-, a CT-scan and MRS-spectroscopy.<br>
Achtergrond van het onderzoek
This study investigates insulin sensitivity at central and peripheral level in patients with familial hypobetalipoproteinemia and compares it to healthy controls. Body fat distribution will be studied as well.
Doel van het onderzoek
Patients with Familial Hypobetalipoproteinemia (FHBL) could have increased hepatic glucose production because of hepatic steatosis. Additionally, peripheral insulin sensitivity could be enhanced since these patients have lower concentrations of intramyocellular lipids.
Onderzoeksopzet
N/A
Onderzoeksproduct en/of interventie
A hyperinsulinaemic clamp will be performed for 4½ hours
using stabile isotopes (d2-glucose and D5-glycerol). Additionally, muscle
biopsies will be taken and fat distribution will be studied by a DEXA-, a
CT-scan and MRS-spectroscopy. Patients with FHBL will be compared to healthy
controls matched for age,sex, BMI and waist circumference.
Publiek
P.O. Box 22660
R. Blumer
Meibergdreef 9
Amsterdam 1100 DD
The Netherlands
+31 (0)20 5669111
r.blumer@amc.uva.nl
Wetenschappelijk
P.O. Box 22660
R. Blumer
Meibergdreef 9
Amsterdam 1100 DD
The Netherlands
+31 (0)20 5669111
r.blumer@amc.uva.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Male;
2. Age > 18 y;
3. BMI 20-35 kg/m2.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Known somatic illness;
2. Use of medication influencing metabolism/ blood clotting;
3. Seropositive for HbsAg, HbcAg, HCV, HAV or HIV;
4. Having metal device in the body.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL608 |
| NTR-old | NTR665 |
| Ander register | : N/A |
| ISRCTN | ISRCTN35161775 |