MEG language and memory mapping: a comparison with WADA.

To reduce the risk of aphasia or amnesia following surgical resection in patients suffering from epilepsy
and/or brain tumours it is necessary to identify language and memory presentation pre-surgically. Of
importance here is to determine whether there is a dominant hemisphere with regards to language and
memory function. Currently, the gold standard for the evaluation of lateralised language and memory
mapping is the Wada procedure. Recent advances in neuroimaging techniques however might provide us
with opportunities to replace this invasive procedure with a non-invasive and cost-effective alternative to
conduct pre-surgical assessment of language and memory function, and in addition, help in the planning
of grid implantations.



Our overall aim is to create a cost effective non-invasive method of pre-surgical assessment of language
and memory function using MEG scanning. We propose a research project with the key objective to
evaluate the effectiveness of a Dutch implementation of a language/memory stimuli and analysis protocol.

Our overall aim is to create a cost effective non-invasive method of pre-surgical assessment of language
and memory function using MEG scanning. We propose a research project with the key objective to evaluate the effectiveness of a Dutch implementation of a language/memory stimuli and analysis protocol.

After inclusion of the last patient.

Language and memory areas will be localised using Magnetoencephalography (MEG). The effectiveness of the protocol will be evaluated by comparison with Wada (intracarotid sodium amobarbital procedure) results.