QEEG profiles in developmental disorders.

The main aim of this study is to search for sensitive and specific QEEG markers to differentiate between children with a developmental disorder, in this case ADHD and ASD, and a control group and to differentiate between these two developmental disorders compared with each other. To do so, the patient groups and the control group are measured with the same equipment, software and measure settings. In this way QEEG outcome across groups can be compared in a reliable and valid way. By means of combining several (non)linear analysis methods QEEG markers for every pathology will be examined and developed and sensitivity and specificity measures of these markers will be calculated.
Additionally the effect of medication (methylphenidate) in children with ADHD on the QEEG profile will be investigated.

1. QEEG markers can differentiate a developmental disorder, in this case ADHD and ASD, not only from a control group but also from each other;

2. QEEG markers are associated with the change in behavioural characteristics after administration of methylphenidate in patients with ADHD.

The total time of the measurements will be 45 tot 60 minutes for each child.

In boys with ADHD, who are taking methylphenidate, the second measurement without medication will be conducted within four weeks.

QEEG measurements under four conditions:

1. Resting with eyes open;

2. Resting with eyes closed;

3. During an attention task;

4. During a motor task.

Parents will have to complete two questionnaires (SDQ and ADHD-Rating Scale). Boys with ADHD who are taking methylphenidate are measured twice: once on a day with medication and once on a day without methylphenidate.