Anorexia nervosa (AN) is a psychiatric disease resulting in severely reduced food intake partly due to altered appetite/satiety balance resulting in very low BMI and the highest mortality rate of all mental illnesses1. Several forms of psychological…
ID
Bron
Verkorte titel
Aandoening
anorexia nervosa
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
the effect of FMT on different microbiota composition in relation to weight, appetite/satiety (fMRI/questionnaires) and Nutrient Drink Test ( incl plasma hormones)
Achtergrond van het onderzoek
we aim to identify driving (microbiota related) factors that can improve metabolic control, food intake and subsequent weight gain in anorexia nervosa patients by infusion donor feces
Doel van het onderzoek
Anorexia nervosa (AN) is a psychiatric disease resulting in severely reduced food intake partly due to altered appetite/satiety balance resulting in very low BMI and the highest mortality rate of all mental illnesses1. Several forms of psychological therapies, with or without medication, have been tried, but have not been very successful. The pathophysiology of AN is incompletely understood, but disturbed intestinal microbiota composition might be involved. Since we have previously shown that fecal microbial transplantation (FMT) has an effect on metabolism, we aim to test this intervention in anorexia nervosa patients.
Onderzoeksopzet
baseline ,6 and 12 weeks
Onderzoeksproduct en/of interventie
single donor fecal transplantation from female donor with BMI of 25 kg/m2 (allogenic) or own (autologous)
Publiek
MEIBERGDREEF 9, KAMER F4.159.2
M. Nieuwdorp
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5666612
m.nieuwdorp@amc.uva.nl
Wetenschappelijk
MEIBERGDREEF 9, KAMER F4.159.2
M. Nieuwdorp
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5666612
m.nieuwdorp@amc.uva.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- Caucasian female
- Older than 18 years
- BMI <17 kg/m2
- Stable medication use
- Meeting the DSM V criteria for anorexia nervosa, restricting type
- able to give informed consent
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- PPI and antibiotics use in last 3 months
- Smoking, XTC, amphetamine or cocaine abuse
- Alcohol abuse (>3/day)
- A concomitant severe psychiatric disorder, such as psychosis, severe depression or a personality disorder that renders them unsuitable for the trial as judged by a psychiatrist
- Participation in a research protocol involving radiation exposure in the last 2 years.
- Contraindication MRI (pregnancy, pacemaker and metals contraindicated for MRI).
- Cholecystectomy
- Expected prolonged compromised immunity (due to recent cytotoxic chemotherapy or HIV infection with a CD4 count < 240)
- Treatable underlying cause of anorexia/underweight
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL6181 |
| NTR-old | NTR6336 |
| Ander register | METC : 2016_180 |