Moderate weight loss increases sensitivity to β2-AR-stimulated lipolysis in isolated adipocytes from subcutaneous adipose tissue biopsies.
ID
Bron
Verkorte titel
Aandoening
Obesity, beta2-adrenergic sensitivity, lipolysis
Obesitas, beta2-adrenerge gevoeligheid, lipolyse
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Changes in sensitivity to β2-AR-stimulated lipolysis in adipocytes isolated from subcutaneous adipose tissue biopsies.
Achtergrond van het onderzoek
This study investigates the effects of weight loss on beta2-adrenergic stimulated lipolysis in isolated adipocytes. In addition the effects of weight loss on adipose tissue hypoxia and adipose tissue and systemic oxidative stress will be determined.
Doel van het onderzoek
Moderate weight loss increases sensitivity to β2-AR-stimulated lipolysis in isolated adipocytes from subcutaneous adipose tissue biopsies.
Onderzoeksopzet
1. Premeasurements will be done before the start of the CO-EUR programme;
2. Postmeasurements will be done after 9 months of participation in the CO-EUR programme. Postmeasurements will be done in every subject, who is still participating in the Co-Eur programme after 9 months, regardless of the amount of weight lost or gained in those 9 months.
Onderzoeksproduct en/of interventie
Subjects follow the standard weight loss programme in Heerlen (NL) provided by CO-EUR without interference by the researchers.
CO-EUR is an obesity treatment centre which uses an 18-month-lasting programme with a multi-disciplinary approach, including diet, physical activity and behaviour change, to treat people with obesity.
Publiek
P.O. Box 616
K.F.M. Teunissen-Beekman
Maastricht 6200 MD
The Netherlands
+31 (0)43 3881635
kfm.teunissen@maastrichtuniversity.nl
Wetenschappelijk
P.O. Box 616
K.F.M. Teunissen-Beekman
Maastricht 6200 MD
The Netherlands
+31 (0)43 3881635
kfm.teunissen@maastrichtuniversity.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. All subjects entering the Co-Eur programme;
2. Age > 18 years old;
3. No more than 3 kg weight change in the past 3 months.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Smoking;
2. Diabetes;
3. (Medicinal) use of β-blockers or β-agonists;
4. Pregnant women;
5. Blood clotting problems or (medicinal) use of anticoagulantia.
Opzet
Deelname
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| Register | ID |
|---|---|
| NTR-new | NL2874 |
| NTR-old | NTR3019 |
| Ander register | METC : 11-3-019 |
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