Reduced numbers of specific CD8+ T cell subsets in frailty elderly correlate with a limited ability to mount robust mucosal T cell responses to control and clear respiratory infections
ID
Bron
Verkorte titel
Aandoening
Respiratory infections, Aging
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
To compare nasal CD8+ T cell frequency between young adults and frail older adults.
Achtergrond van het onderzoek
Rationale: Individuals with advanced age are at a progressively increasing risk of acquiring lower respiratory tract infections. Besides calendar age, the degree of frailty also associates with increased susceptibility to pneumonia requiring hospitalization. How alterations in the mucosal immune system with advanced age predispose to infections remains unclear as access to relevant tissue samples is limited. With minimally-invasive nasal sampling methods, we recently observed that in vital older adults, both CD4+ T cells and CD8+ T cells are selectively lost from the nasal mucosa. However, the exact phenotype, underlying mechanisms, key molecules and consequences of this have not yet been investigated.
Objective: Here, we aim to elucidate the mechanisms underlying the loss of nasal T cells and characterize in depth the differences of T cells in young and older adults and associate this loss with susceptibility to infections
Doel van het onderzoek
Reduced numbers of specific CD8+ T cell subsets in frailty elderly correlate with a limited ability to mount robust mucosal T cell responses to control and clear respiratory infections
Onderzoeksopzet
*day of recruitment
*2-4 months after recruitment
(when respiratory infection occurs within study time-frame, than we will sample at: moment of infection, 1, 3 and 5 months after infection)
Onderzoeksproduct en/of interventie
N/A
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
• Healthy elderly (>65yrs) that are not frail (frailty score 1-3)
• Frailty (frailty score ≥4) elderly (>65yrs) These will be consist of individuals without a history of recurrent respiratory infections or with >2 self-reported episodes of respiratory infection in the past year.
• Healthy young (18-35yrs) adults
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
• Incompetence to provide informed consent prior or during study
• Current smoker or >40 pack year history
• History of severe nose bleedings
• Diagnosed with asthma, COPD or chronic rhinosinusitis
• Use of inhalation corticosteroids or antibiotics in the past 6 weeks
• Current use of anti-coagulants (to prevent nosebleeds)
• Respiratory tract infection or common cold in the past 2 weeks
• Immunocompromised individuals (with primary immune deficiency or secondary immune deficiency)
• Life expectancy <28 days in the opinion of study physician
• Vaccination in the 2 months prior to study start
A potential subject that is only excluded from participation based on a recent vaccination will be asked to re-participate 2 months post vaccination.
Opzet
Deelname
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| Register | ID |
|---|---|
| NTR-new | NL9796 |
| Ander register | METC LDD : METC NL77841.058.21 |