Metabolic syndrome is more frequent in long-term survivors of childhood cancer compared with healthy controls.
ID
Bron
Aandoening
Engels:
Childhood cancer survivors
Metabolic syndrome
Cardiovascular risk factors
Adrenal function
Physical activity
Nederlands:
Overlevenden van kinderkanker
Metabool syndroom
Cardiovasculaire risicofactoren
Bijnierfunctie
Lichamelijke activiteit
Ondersteuning
Principal investigators:
Drs. M. van Waas
Dr. M.M. van den Heuvel-Eibrink
Drs. S.C.J.M.M. Neggers
Prof. Dr. R. Pieters
Kinderen Kankervrij (KiKa)
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
METABOLIC SYNDROME:<br>
1. Waist circumference (high in males when >102cm and in females when >88cm);<br>
2. Waist/Hip ratio (high when >0.9);<br>
3. Fasting plasma glucose (high when >=5.6 mmol/l));<br>
4. Triglycerides (high when >=1.7 mmol/l);<br>
5. HDL-cholesterol (high in males when <1.03 and in females when <1.3);<br>
6. Blood pressure (high when >= 130/85).
<br><br>
CARDIOVASCULAR RISK FACTORS:<br>
Imaging studies:<br>
1. Ultrasound of carotids for measurement of intima media thickness;<br>
2. Pulse wave velocity;<br>
3. Ultrasound of abdominal fat (subcutaneous and preperitoneal).<br>
Laboratory investigations:<br>
1. Uric acid;<br>
2. Cystatin C;<br>
3. Lipidspectrum (total cholesterol, LDL, VLDL, HDL, free fatty acids, triglycerides, apolipoprotein A and B);<br>
4. Thrombotic factors (Antithrombine III, Protein C and S, homocysteine, Plasminogen activator inhibitor-1 (PAI1), routine clotting parameters);<br>
5. Pro-inflammatory markers (TNF-α, IL-6, (high sensitivity)-CRP);<br>
6. Endocrine tests (free T4, TSH, cortisole rhythm (from saliva), IGF-1, IGF-BP-3 and BP-1, ACTH, and routine fertility screening (In females: AMH, Inhibin A en B, DHEA. If not on contraceptives: FSH, LH, oestradiol, progesterone, SHBG. In males: Inhibin B, AMH, testosterone, LH, FSH, SHBG);<br>
7. Insulin;<br>
8. Biomarkers for adiposity (leptin, adiponectin, adipokine);<br>
9. Molecular analyses of genetic aberrations associated with risk factors for elevated metabolic syndrome, i.e. (P207L, D9N mutations in the lipoprotein lipase gene) peroxisome proliferative-activated receptor gamma2 (PPARγ2, aldose reductase, ABCG5 and ABCG8, SUR1, Kir 6-2 gene aberrations, Lipin1 SNPs, AMH SNPs;<br>
10. ALAT, ASAT, gamma-GT;<br>
11. Urine analysis: Microalbuminuria and albumin/creatinin ratio.
Achtergrond van het onderzoek
N/A
Doel van het onderzoek
Metabolic syndrome is more frequent in long-term survivors of childhood cancer compared with healthy controls.
Onderzoeksopzet
All measurements will be performed on one day.
Onderzoeksproduct en/of interventie
N/A
Publiek
Sophia Children's Hospital,
Department of Oncology/Hematology,
P.O. Box 2060
M.M. Heuvel-Eibrink, van den
Dr. Molewaterplein 60
Rotterdam 3000 CB
The Netherlands
m.vandenheuvel@erasmus.nl
Wetenschappelijk
Sophia Children's Hospital,
Department of Oncology/Hematology,
P.O. Box 2060
M.M. Heuvel-Eibrink, van den
Dr. Molewaterplein 60
Rotterdam 3000 CB
The Netherlands
m.vandenheuvel@erasmus.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Patients:
1. ≥ 18 years old at January 1st in the year they will be recruited;
2. History of childhood cancer;
3. ≥5 years after cessation of therapy;
4. Treated at the Erasmus MC-Sophia Children’s Hospital.
Controls:
1. Brother or sister of the patient;
2. Friend or neighbour of the patient, of the same sex and within an age range of 5 years.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Patients: (Partly) Treated in other country;
Controls: A history of childhood cancer.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL2685 |
| NTR-old | NTR2814 |
| Ander register | METC Erasmus MC : 2009-030 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |