Type 2 diabetes is a major threat to human health. Disruption of the circadian timing system is associated with metabolic changes. Disturbance of the daily light and dark rhythm could contribute to this phenomenon and effects metabolic pathways. We…
ID
Bron
Verkorte titel
Aandoening
glucose metabolism
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
To investigate the effect of morning light exposure on postprandial glucose excursions and expression of metabolic and clock genes in adipose tissue.
Achtergrond van het onderzoek
N/A
Doel van het onderzoek
Type 2 diabetes is a major threat to human health. Disruption of the circadian timing system is associated with metabolic changes. Disturbance of the daily light and dark rhythm could contribute to this phenomenon and effects metabolic pathways. We hypothesize that mornig bright light exposure decreases postprandial glucose excursion in obese subjects with and without type 2 diabetes.
Onderzoeksopzet
Frequent plasma measurements of glucose, insulin, C-peptide, free fatty acid and triglyceride. Adipose tissue biopsy at one timepoint. Continous measurement of heart rate variability and skin temperature.
Onderzoeksproduct en/of interventie
Subject will be admitted in the evening and receive a standard meal in normal room light. They sleep for 8 hours in the dark. From wake-up time they consume a standard liquid in bright or dim light.
Publiek
Department of Endocrinology and Metabolism<br>
Academic Medical Center, Amsterdam
D.J. Stenvers
Amsterdam
The Netherlands
+31 (0)20 5663507
d.j.stenvers@amc.uva.nl
Wetenschappelijk
Department of Endocrinology and Metabolism<br>
Academic Medical Center, Amsterdam
D.J. Stenvers
Amsterdam
The Netherlands
+31 (0)20 5663507
d.j.stenvers@amc.uva.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Group2
1. Age 18-80 years;
2. Male sex;
3. BMI >25 kg/m2
4. DM2: Fasting plasma glucose >6.9 mmol/L;
5. Habitual wake-up time between 6:00 and 9:00.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Medication interfering with glucose metabolism or neuronal synaptic transmission;
2. Gastro-intestinal or metabolic disease that will interfere with digestion or metabolism;
3. Neuropsychiatric illness including severe depression;
4. Epilepsy;
5. Hypertension;
6. Ophthalmological abnormalities.
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL4141 |
| NTR-old | NTR4645 |
| Ander register | METC AMC : 2013_259 METC AMC |
Samenvatting resultaten
Smilde AK, Fliers E, Kalsbeek A, Serlie MJ, la Fleur SE, Bisschop PH. Acute
Effects of Morning Light on Plasma Glucose and Triglycerides in Healthy Men and
Men with Type 2 Diabetes. J Biol Rhythms. 2017 Apr;32(2):130-142. doi:
10.1177/0748730417693480. Epub 2017 Mar 20. PubMed PMID: 28470119; PubMed Central
PMCID: PMC5423535.