Is it possible to construct intraoperative left ventricular end-systolic pressure-volume relations from a combination of non-invasive finger arterial blood pressure measurements and transoesophageal echocardiography in patients undergoing surgery?
ID
Bron
Verkorte titel
Aandoening
Intraoperative cardiac monitoring, left ventricular function
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Is it possible to reconstruct intraoperative left ventricular end-systolic pressure-volume relations from a combination of non-invasive finger arterial blood pressure measurements and transesophageal echocardiography in patients undergoing surgery?
Achtergrond van het onderzoek
In this study we will investigate a method combining transoesophageal echocardiography and non-invasive finger arterial blood pressure waveforms to non-invasively construct pressure-volume (P-V) loops to describe the end-systolic pressure-volume relations in the heart. This may provide a method to obtain more insight on cardiac contractile function and the interaction of the heart with the vasculature during surgery.
Doel van het onderzoek
Is it possible to construct intraoperative left ventricular end-systolic pressure-volume relations from a combination of non-invasive finger arterial blood pressure measurements and transoesophageal echocardiography in patients undergoing surgery?
Onderzoeksopzet
All measurement will take place in the operating room during surgery.
Onderzoeksproduct en/of interventie
Besides standard intraoperative monitoring, patients will receive the following:
1. Transoesophageal echocardiography;
2. Continuous noninvasive finger blood pressure measurements using the Nexfin;
3. Inferior Vena cava occlusion for 15 seconds;
4. Administration of Fenylephrine intravenously.
Publiek
Afdeling anesthesiologie
Catharina Ziekenhuis Eindhoven
Eindhoven
The Netherlands
arthur.bouwman@catharinaziekenhuis.nl
Wetenschappelijk
Afdeling anesthesiologie
Catharina Ziekenhuis Eindhoven
Eindhoven
The Netherlands
arthur.bouwman@catharinaziekenhuis.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Patients scheduled for:
A. Open abdominal surgery via laparotomy;
B. Cardiac surgery, Coronary Artery Bypass Graft.
2. Age 18-75 years;
3. Informed consent.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Group A specific:
1. Known / documented cardiac disease;
2. ECG / echocardiography abnormalities.
All subjects group A + B:
1. Contraindications for TEE;
2. Contraindications for arterial line;
3. Contraindications for administration of phenylephrine.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
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Andere (mogelijk minder actuele) registraties in dit register
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL2800 |
| NTR-old | NTR2941 |
| Ander register | VUmc department of Anesthesiology : ANES 2011/01 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |