Consumption of foods containing L-arabinose will improve glycaemic and insulinemic response.
ID
Bron
Verkorte titel
Aandoening
eating behaviour, overweight, obesity, nutritional disorders en metabolic diseases (incl. diabetes)
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
blood glucose and insulin levels
Achtergrond van het onderzoek
L-arabinose is a pentose which is naturally present in plants. L-arabinose can act as a sugar substitute in many foods, among which drinks and cereal clusters.
The main objective is to determine and compare the effect of partly substituting sucrose by L-arabinose in a sucrose solution and in a cereal cluster on glycaemic responses and insulinemic responses in healthy humans. Secondary objectives are: To determine and compare the effect of partly substituting sucrose by L-arabinose in a sucrose solution and in a cereal cluster on: 1) the absorption and excretion of L-arabinose. 2) plasma GLP-1 concentration. 3) subsequent ad libitum energy intake. 4) appetite feelings. 5) the acceptability of the treatments as measured by gastro-intestinal comfort.
The study is a randomized within blocks, cross-over study. The liquids treatment is open labelled, for the cereal clusters the study is double-blind. All subjects will receive six interventions in an order randomized within solutions and cereal clusters. The food products will be consumed in fasting state as a breakfast. All control products contain 50g available carbohydrates. In the drinks, one treatment 30% (i.e. 15g) of the sucrose will be replaced by L-arabinose, the other treatment 15g L-arabinose without sucrose will be added to water; in the cereal clusters 10% and 15% sucrose will be replaced by L-arabinose.
Eighteen healthy adults between 18-35y old will be included.
The food products will be consumed in fasting state as a breakfast. All control products contain 50g available carbohydrates.
Doel van het onderzoek
Consumption of foods containing L-arabinose will improve glycaemic and insulinemic response.
Onderzoeksopzet
Every subject will visit the research site 8 times:
1: For an information meeting;
2: For a screening meeting;
3: 6 test sessions
A. Blood collection and appetite feelings by VAS questionnaire: baseline, 15, 30, 45, 60, 90, 120, 180 minutes after start of the treatment;
B. Ad libitum test meal at 190 minutes after start of the treatment;
C. Gastro-intestinal comfort at baseline, 3, 6 and 9 hours after start of the treatment.
Onderzoeksproduct en/of interventie
1) Sugar drink; 2) L-arabinose and Sugar drink; 3) L-arabinose drink; 4) Sugar clusters; 5) L-arabinose clusters low dose; 6) L-arabinose clusters high dose
Publiek
Korrie Pol
Postbus 8129
Wageningen 6700 EV
The Netherlands
korrie.pol@wur.nl
Wetenschappelijk
Korrie Pol
Postbus 8129
Wageningen 6700 EV
The Netherlands
korrie.pol@wur.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
• 18-35 Years old while signing the informed consent
• Good Dutch speaking, writing, understanding
• Healthy: as judged by the subject
• Stable body weight, i.e. no reported weight loss or weight gain of > 5 kg in the two months prior to the screening session
• Normal fasting glucose concentration <6.1 mmol/L, measured by finger prick
• Normal hemoglobine (Hb) concentration >8.5 mmol/L for men and >7.5 mmol/L for females, measured by finger prick
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
• Women being pregnant or lactating
• Allergy, intolerance or oversensitivity for food products
• Having reported gastro-intestinal problems
• Having a history of medical or surgical events that may affect the study outcome
• Medical drug use (except for contraceptives) that may affect the study outcome
• Current antibiotics usage or in the two months prior to the screening session
• Not willing to eat or drink the test products
• Use of dietary supplements that may affect the study outcome
• Currently using a slimming or medically prescribed diet or having used one in the two months prior to the screening session
• Excessive alcohol consumption (>21 glasses/week on average)
• Planning to change physical activity pattern during the study period
• Having blood vessels that are too difficult for inserting a cannula, as judged by the study nurse
• Recent blood donation (<1 month prior to Day 1 of the study)
• Planning to donate blood as a blood donor during the study
• Not having a general practitioner
• Being an employee or student doing a thesis or internship of Wageningen University, department of Human Nutrition
• Current participation in other research
Opzet
Deelname
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In overige registers
Register | ID |
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NTR-new | NL5775 |
NTR-old | NTR5929 |
Ander register | METC-WU 15/33 : ABR: NL55974.081.15 |