We hypothesize that black tea ingestion (approximately 530 mg tea polyphenols) in healthy middle-aged humans will lead to a larger mean forearm blood flow response to acetylcholine (i.e. endothelium-dependent vasodilation) We hypothesize that black…
ID
Bron
Aandoening
Vascular function; endothelial function; black tea; healthy volunteers; blood flow; blood pressure; hypertension
vaatfunctie; zwarte thee; endotheel; gezonde vrijwilligers; bloeddruk; hypertensie
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Mean forearm blood flow response (volume change measured by venous occlusion plethysmography) to intra-arterially administered acetylcholine (i.e. endothelium-independent vasodilation)
Achtergrond van het onderzoek
Previous research showed that, even small amounts of, black tea lowers blood pressure in healthy people and people with hypertension.
In this study, we will investigate the effects of acute ingestion of black tea to endothelial function by venous occlusion plethysmography in healthy volunteers. We will study the mechanism underlying the blood pressure lowering effects of black tea.
Voorgaand onderzoek heeft laten zien dat zwarte thee de bloeddruk verlaagd, zowel bij gezonden mensen als mensen met een verhoogde bloeddruk. In deze studie willen we de acute effecten van het drinken van zwarte thee onderzoeken met veneuze occlusie plethysmografie bij gezonde vrijwilligers. Op deze manier onderzoeken we het mechanisme dat ter grondslag ligt aan de bloeddrukverlagende effecten van zwarte thee.
Doel van het onderzoek
We hypothesize that black tea ingestion (approximately 530 mg tea polyphenols) in healthy middle-aged humans will lead to a larger mean forearm blood flow response to acetylcholine (i.e. endothelium-dependent vasodilation)
We hypothesize that black tea ingestion (approximately 530 mg tea polyphenols) in healthy middle-aged humans will not change mean forearm blood flow response to sodium nitroprusside (i.e. endothelium-independent vasodilation)
We hypothesize that black tea ingestion (approximately 530 mg tea polyphenols) in healthy middle-aged humans will lead to a larger decline in mean forearm blood flow response to L-NMMA (i.e. nitric oxide-blocker; endothelium-dependent vasoconstriction)
Onderzoeksopzet
not applicable; cross-over design
Onderzoeksproduct en/of interventie
ingestion of black tea vs placebo-tea
Publiek
Dick H.J. Thijssen
Nijmegen 6525 EX
The Netherlands
+31 (0)24 3614222
d.thijssen@fysiol.umcn.nl
Wetenschappelijk
Dick H.J. Thijssen
Nijmegen 6525 EX
The Netherlands
+31 (0)24 3614222
d.thijssen@fysiol.umcn.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Healthy subjects:
- Males and post-menopausal (> 1 years) females
- Aged >45 and < 75 years
- Body mass index (BMI) between 18.0 and „T35.0 kg
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Regular performance of strenuous exercise/sport of > 2 hours per week
- Current smoker or has stopped smoking less than 6 months before start of study
- Self reported alcohol intake of >21 units/week)
- Established cardiovascular disease
- Diabetes mellitus
- Blood pressure > 160/100 mmHg
- Subjects taking any medication that might affect endothelial function (e.g. but not limited to beta-blockers, ACE-inhibitors, statins, anti-coagulants, anti-depressants, hormone replacement therapy) will be excluded from the study. Subjects who are on stable medication for which there is no indication of an effect on endothelial function, will be allowed to participate.
Opzet
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL4789 |
| NTR-old | NTR4929 |
| Ander register | : CMO 2014-1264 |