The current study evaluates whether accurate optical diagnosis of small colorectal polyps (
ID
Bron
Verkorte titel
Aandoening
differentiation, colonoscopy, white light, WavSTAT, optical diagnosis
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
1. The overall accuracy of the WavSTAT represented by the sensitivity and specificity using final histopathology as golden standard;<br>
2. The accuracy of the WavSTAT of lesions that are differentiated with white light endoscopy with low confidence, represented by the sensitivity and specificity using final histopathology as golden standard.
Achtergrond van het onderzoek
WavSTAT (Spectrascience, Inc., San Diego, CA, USA) is an optical biopsy system that can aide endoscopists in differentiation of colorectal lesions. Accurate differentiation of small colorectal lesions can result in removal of these lesions without formal histopathology making colonoscopy more efficient and cost-effective.
The laser light of the WavSTAT is absorbed by colonic tissue resulting in an autofluorescent return signal, which is subsequently analysed. Within seconds a ‘non-adenomatous’ or ‘adenomatous’ result is displayed on a screen. The WavSTAT can be particularly useful as an add-on technique for differentiation of colorectal lesions that the endoscopist differentiates with low confidence using white light (WL).
The aim of the current study is to assess the sensitivity, specificity and accuracy of an algorithm combining WL and WavSTAT. In this algorithm, overall accuracy is defined by WL in high confidence lesions and by WavSTAT in low confidence lesions.
Doel van het onderzoek
The current study evaluates whether accurate optical diagnosis of small colorectal polyps (<10mm) can be achieved using both the endoscopic image as well as an optical device called the WavSTAT. Accurate optical diagnose could result in the omission of formal histopathology, which could make colonoscopy more efficient and cost effective.
Onderzoeksopzet
N/A
Onderzoeksproduct en/of interventie
N/A
Publiek
Department of Gastroenterology and Hepatology <br>
P.O. Box 22660
Evelien Dekker
Meibergdreef 9
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5664702
e.dekker@amc.uva.nl
Wetenschappelijk
Department of Gastroenterology and Hepatology <br>
P.O. Box 22660
Evelien Dekker
Meibergdreef 9
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5664702
e.dekker@amc.uva.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Age > 18 years;
2. Patients who are advised to undergo colonoscopic surveillance because of:
A. A history of adenomatous polyps;
B. Symptoms (e.g. change in bowel habits);
C. Family history of CRC.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Poor bowel preparation (scoring ≤ 4 points on the Boston Bowel Preparation Scale 8);
2. Polyposis syndromes;
3. History of inflammatory bowel disease;
4. Presence of conditions precluding histological sampling of the colon (e.g. coagulation disorders, anticoagulant therapy).
Opzet
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| Register | ID |
|---|---|
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