Our hypothesis is that the ratio omalizumab trough-level to baseline IgE differs from the 15:1 ratio, which was found to induce adequate asthma-suppression in early trials. The patients yearn for the next gift may be associated with an inadequate…
ID
Bron
Verkorte titel
Aandoening
Allergic Asthma
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The percentage of patients with a ratio omalizumab trough-level to baseline IgE larger than 15:1
Achtergrond van het onderzoek
Omalizumab has been used in the treatment of severe allergic asthma for several years. Early trials found that adequate suppression of IgE was achieved when omalizumab was in excess over IgE 15:1. It remains unknown what this ratio is in patients treated for more than a year. Furthermore, some patients are able to extend their dose-interval, while some patients indicate that they yearn for their next omalizumab gift. In this trial the ratio between trough omalizumab-level and baseline IgE will be examined. The patients yearn for the next gift and the correlation with the ratio between trough omalizumab-level and baseline IgE will be examined.
Doel van het onderzoek
Our hypothesis is that the ratio omalizumab trough-level to baseline IgE differs from the 15:1 ratio, which was found to induce adequate asthma-suppression in early trials.
The patients yearn for the next gift may be associated with an inadequate ratio.
Onderzoeksopzet
Data will be collected during the 6-month evaluation
Onderzoeksproduct en/of interventie
N/A
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Severe asthma patients, receiving more than 12 months of omalizumab therapy, >18 months old, able to sign informed consent.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
None
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
Toelichting
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL7794 |
| Ander register | RTPO Leeuwarden : nWMO 375 |