Objective of this study is to assess the sensitivity of performance in a number of widely used tests for measuring driver impairment to the dose-effects of alcohol.
ID
Bron
Aandoening
dose effects of alcohol
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Dual task performance using a divided attention task. The task combines psychomotor tracking test with peripheral visual search task. Dependent measures are speed and accuracy of responses in both subtasks
Achtergrond van het onderzoek
Use of psychoactive medication is associated with increased risks of motor vehicle accidents. New psychoactive medications should therefore be screened early in development for their potential to impair driving related skills. There is no consensus however on the performance test(s) that can be recommended for such purposes. The purpose of this study is therefore to compare the sensitivity of a number of available tests to drug-induced impairment by comparing the dose-effects of alcohol on performance. Twenty-four healthy male and female volunteers will participate in this 4-way double blind crossover design. Alcohol treatment consists of pure ethanol (mixed orange juice) in gender and weight adjusted doses to reach blood alcohol concentrations of 0.0, 0.2, 0.5 and 0.8 mg/ml. Performance tests will be conducted within two hours after each dose of alcohol.
Doel van het onderzoek
Objective of this study is to assess the sensitivity of performance in a number of widely used tests for measuring driver impairment to the dose-effects of alcohol.
Onderzoeksopzet
Acute effects. Performance is assessed within two hours after each dose of alcohol.
Onderzoeksproduct en/of interventie
Single oral doses of ethanol mixed with orange juice sufficient to raise Blood Alcohol Concentrations to approximately 0.2, 0.5 and 0.8 mg/ml, and placebo (orange juice only).
Publiek
Maastricht University<br>
PO Box 616
A. Vermeeren
Maastricht 6200 MD
The Netherlands
+31 (0)43 3881952
a.vermeeren@maastrichtuniversity.nl
Wetenschappelijk
Maastricht University<br>
PO Box 616
A. Vermeeren
Maastricht 6200 MD
The Netherlands
+31 (0)43 3881952
a.vermeeren@maastrichtuniversity.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Healthy males and females;
2. Aged between 18 and 30 yrs;
3. BMI between 19 and 29 m2/kg;
4. Social drinkers.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. History or mental illness;
2. Current physical illness;
3. Use of medication or drugs;
4. Drinking less than 3 glasses alcohol per week or more than 21 glasses of alcohol per week;
5. Execessive use of caffeine or nicotine.
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL3153 |
| NTR-old | NTR3297 |
| Ander register | METC : 12-3-001 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |