- Working memory training is effective to treat heavy cocaine use - N-acetylcysteine treatment is effective to treat heavy cocaine use - the combination of both is expected to be most effective
ID
Bron
Verkorte titel
Aandoening
cocaine dependence, cocaine afhankelijkheid
addiction, verslaving
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
- cocaine use <br>
-glutamatergic concentrations in the dorsal ACC and rostral ACC <br>
- working memory improvement <br>
- craving
Doel van het onderzoek
- Working memory training is effective to treat heavy cocaine use
- N-acetylcysteine treatment is effective to treat heavy cocaine use
- the combination of both is expected to be most effective
Onderzoeksopzet
t0= baseline measures before treatment;
t1-t25= daily intermediate measure at home during treatment + 5 times contact by phone;
t26= post-treatment measures;
t27= follow-up
Onderzoeksproduct en/of interventie
- 25 days working memory or placebo training
- 25 days 2400 mg/d N-Acetylcysteine capsules or placebo capsules
This results in 4 groups: (1) working memory training and N-acetylcysteine, (2) working memory training and placebo capsules, (3) placebo training and n-acetylcysteine, (4) placebo training and placebo capsules
Publiek
University of Amsterdam<br>
Department of Psychiatry<br>
PA3-225<br>
P.O. box 22660
Mieke Mors-Schulte, ter
Amsterdam 1100 DD
The Netherlands
+31 (0)20 8913704
m.termors.schulte@gmail.com
Wetenschappelijk
University of Amsterdam<br>
Department of Psychiatry<br>
PA3-225<br>
P.O. box 22660
Mieke Mors-Schulte, ter
Amsterdam 1100 DD
The Netherlands
+31 (0)20 8913704
m.termors.schulte@gmail.com
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. males
2. 18 -60 years old
3. minimal 2 DSM-5 critieria AND using cocaine at least 4 times per month
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Major illnesses;
2. Two or more DSM-5 substance use disorder criteria for heroin
3. Ulcers;
4. MRI incompatibility
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL4326 |
| NTR-old | NTR4474 |
| CCMO | NL54240.094.15 |
| OMON | NL-OMON43722 |