Survival of transfused erythrocytes will depent on donor and unit characteristics
ID
Bron
Verkorte titel
Aandoening
Sickle cell disease & β-thalassemia
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The primary outcome is the survival of transfused RBCs in patients with sickle cell disease and β-thalassemia.
Achtergrond van het onderzoek
Rationale: Red blood cell (RBC) transfusions are currently one of the most important therapeutic options for patients with sickle cell disease and β-thalassemia. Over the last years much research has been conducted to improve transfusion safety, especially focussing on antigen matching to prevent alloimmunization. However, the fate of transfused RBC in these patients is largely unknown. Until now it has been difficult to track RBCs once transfused. A recently developed method (biotinylation of RBC units) allows a robust analysis of survival and clearance of the transfused RBCs. Insight in these phenomena may help to elucidate individual variation of RBC survival and behaviour in these patients.
Our objective is to assess the survival of transfused red blood cells (RBC) in patients with sickle cell disease and β-thalassemia by use of biotin labeled RBCs
Doel van het onderzoek
Survival of transfused erythrocytes will depent on donor and unit characteristics
Onderzoeksopzet
T-1: Analysis of blood group genes
T0: Pre transfusion
T1: 10 minutes after transfusion
T2: 2 hours after transfusion
T3: 1 day after transfusion
T4: 10-12 days after transfusion
T5: 4-6 weeks after transfusion
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
• Patient with either sickle cell disease (HbSS/HbSβ0/HbSC/HbSβ+) or β-thalassemia (major or transfusion dependent thalassemia intermedia)
• Currently on chronic transfusion program.
• >18 years of age
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
No venous access for blood drawings
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL7734 |
| Ander register | METC AMC : 2018_299 |