We hypothesise that dosing using tablets of half a milligram acenocoumarol increases anticoagulation control
ID
Bron
Verkorte titel
Aandoening
Atrial fibrillation, venous thrombo-embolism, heart valve repair
Boezemfibrilleren, trombose, longembolie, hartklepvervanging
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The main study parameter is quality of anticoagulation (individual time in therapeutic range and INR variability).
Achtergrond van het onderzoek
More precise dosing of acenocoumarol in patients aged 80
and above, a pilot study
Doel van het onderzoek
We hypothesise that dosing using tablets of half a milligram acenocoumarol increases anticoagulation control
Onderzoeksopzet
Start of study, six months later
Onderzoeksproduct en/of interventie
One group is dosed using tablets of 0.5 milligrams of acenocoumarol, while the other group uses the regular 1.0 milligram tablets. Both will be dose-adjusted to their previously determined INR target range.
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
In order to be eligible to participate in this study, a subject must meet all of the following criteria:
- Using acenocoumarol for any indication, and being managed by Certe Trombosedienst
- 80 years of age or older at time of inclusion
- Using acenocoumarol with an average daily dose of less than 2 milligrams in the previous three months
- Subject provided informed consent
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
A potential subject who meets any of the following criteria will be excluded from participation in this study:
- Initiated therapy with acenocoumarol in the last nine months
- Expected termination of VKA within six months
- Dosing step lower than or equal to "step 7", i.e. usage of less than 3.5 milligrams acenocoumarol per week. Patients who use such a low dose generally have an unfavourable prognosis.
- Patients who determine the acenocoumarol dose themselves
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
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Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL5905 |
| NTR-old | NTR6093 |
| Ander register | UMCG Research Registry : 2016 006 20 |