To compare live birth rates among patients receiving cryo thawed embryo transfer after endometrial preparation with estrogen/progesterone substitution and patients receiving cryo thawed embryo transfer in a natural cycle.
ID
Bron
Verkorte titel
Aandoening
EN: subfertility, cryo thawed embryo transfer, IVF
NL: subfertiliteit, gecryopreserveerder embryo's, IVF
Ondersteuning
dr. BJ Cohlen & drs. ER Groenewoud
Postbus 10400
8000 GK Zwolle
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Live birth rate.
Achtergrond van het onderzoek
Cryopreservation of embryos derived from IVF or IVF-ICSI treatment is a save and cost efficient supplement to regular IVF treatment. Before transferring the embryo’s into the uterus it’s necessary to synchronise development of embryo and endometrium. This synchronisation is essential for the success of the treatment. Because of this need cryo embryo transfer needs planning en preparation. The are several methods of endometrial preparation preceding frozen thawed embryo transfer. Most common are natural cycle and artificial cycle preparation. Both are accepted methods of endometrium preparation and it’s common opinion that live birth rates are comparable. Despite this claim so far no randomised study has been undertaken to confirm this statement.
Doel van het onderzoek
To compare live birth rates among patients receiving cryo thawed embryo transfer after endometrial preparation with estrogen/progesterone substitution and patients receiving cryo thawed embryo transfer in a natural cycle.
Onderzoeksopzet
No interim analysis will be performed. Total duration of the study will be 3 years (+ 9 months follow up of pregnant subjects).
Onderzoeksproduct en/of interventie
Cryo thawed embryo transfer in natural cycle versus artificial cycle.
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Patients between 18 en 40, planning to receive a frozen thawed embryo transfer, embryos orginated out of IVF/ICSI treatment 1,2 or 3.
2. Patients are willing to participate during 1 frozen thawed embryo transfer treatment cycle and are willing to sign informed consent.
3. Ovulatoir menstruationcycle between 26 and 35 days.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Patients with a contraindication for medication used in this study such as:
1. Trombo-embolic event in the patients history;
2. Severe disorder of liverfunction;
3. Estrogen sensitive tumors;
4. Breastcancer;
5. Porfyria;
6. Patients with a known allergy for one of the used medicines;
7. Patients with anovulatory menstruation cycles;
8. Patients with uterine abnormalities;
9. Patients with cryo embryos derrived from oocyte donation.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL1515 |
| NTR-old | NTR1586 |
| Ander register | ABR/eudraCT : 23273/2008-002689-68 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd |