CLE provides real-time and high detailed information about the characteristics of the alveolar compartment in mechanically ventilated COVID19 patients.
ID
Bron
Verkorte titel
Aandoening
ARDS, COVID19
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Identification of specific CLE patterns of the alveolar compartment in invasively ventilated COVID 19 patients
Achtergrond van het onderzoek
Acute respiratory distress syndrome (ARDS) is an infrequent but severe complication of COVID 19. The clinical syndrome of ARDS includes a heterogeneous group of patients with varying underlying pathophysiology. The innovative probe-based imaging techniques ‘Confocal Laser Endomicroscopy’ (CLE) is a high-resolution optical technique that, combined with conventional bronchoscopy, has been found to provide real-time, near-histology information about the alveolar compartment. We aim to describe different CLE characteristics of ARDS patients.
Doel van het onderzoek
CLE provides real-time and high detailed information about the characteristics of the alveolar compartment in mechanically ventilated COVID19 patients.
Onderzoeksopzet
24 hours of follow up after CLE procedure
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- ≥18 years of age
- Non-resolving acute respiratory failure mandating a standard diagnostic bronchoscopy with bronchoalveolar lavage
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Inability and willingness to provide informed consent by family-members
- Patients on extra corporal membrane oxygenation (ECMO)
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL9281 |
| Ander register | METC AMC : 2020_294 |