Evaluating patient reported outcomes in the treatment practice of patients with rheumatoid arthritis

This is a prospective observational study, addressing the relationship between DAS28 scores and RAPID3 questionnaires during the treatment of rheumatoid arthritis in adults. Four rheumatologists each assessed patients with rheumatoid arthritis in “real time” clinical care. The rheumatologist or nurse practioner performed a 28-joint count. Patients,recruited in the Netherlands, are emailed and asked to complete the RAPID3 questionnaire. The questionnaire takes 5-10 minutes to complete. The performed RAPID3 will be compared with the DAS28 on a 0-30 versus 1-10 scale. Scores are classified as high activity, moderate activity, low activity, and remission according to the DAS28 and RAPID3 scores. The DAS28 and RAPID3 scores will be statistically compared with a spearman’s rank correlation and with Cohen's kappa coefficient. The questionnaire is processed by an online data portal, which is protected and certified with ISO 9001/ ISO 27001.

The validated health assessment questionnaire (HAQ) such as the RAPID3, gives the rheumatologist the opportunity to have a more frequent and objective view on the effectivity and safety of the treatment. There is a relation between the RAPID3 and the DAS28 in clinical practice.

% with Routine Assessment of Patient Index Data with 3 measures (RAPID3) Timepoints: 4 times a year. % with Disease Activity Score in 28 joints (DAS28) Timepoints: 4 times a year.

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