Despite pre-clinical evidence the effectiveness of curcumin in clinical trails is limited. Currently foodsupplements are available as over the counter products with probably fallacious claims about the bioavailability. Prices of 40-50 euros per…
ID
Bron
Verkorte titel
Aandoening
Curcumin
Piperine
Genistein
Bioavailability: biologische beschikbaarheid
Oncology: Oncologie
digestive system: maag darmstelsel
blood vessel pathologie; bloedvataandoeningen
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The aim of this study is to investigate if curcumin is detectable when patients use curcumin supplements in daily life.
Achtergrond van het onderzoek
The aim of the study is to investigate if curcumin is detectable when subjects use curcumin supplements in daily life.
During a single visit to the hospital a questionnaire about the food supplement use by subjects and two blood samples will be collected. One sample before intake and one sample after intake of the food supplement.
With a validated method the concentrations of curcumin, piperin and genistein and their metabolites will be measured.
Doel van het onderzoek
Despite pre-clinical evidence the effectiveness of curcumin in clinical trails is limited. Currently foodsupplements are available as over the counter products with probably fallacious claims about the bioavailability. Prices of 40-50 euros per bottel of curcumin with or without piperin or genistein are common. Despite this patients currently use this supplement in additional care. In this pilot research we want to investigate which products, formulations and dosages patients use and measure the plasma levels reached during intake of these supplements.
Onderzoeksopzet
17-okt-2016 start of study
Onderzoeksproduct en/of interventie
none
Publiek
J.K. Berbee
Meibergdreef 9
Amsterdam 1105AZ
The Netherlands
+31- (0)20-5663871/+31-(0)20-5669111
j.k.berbee@amc.uva.nl
Wetenschappelijk
J.K. Berbee
Meibergdreef 9
Amsterdam 1105AZ
The Netherlands
+31- (0)20-5663871/+31-(0)20-5669111
j.k.berbee@amc.uva.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Adults, currently using curcumin foodsupplement as a over the counter product, patient in AMC, able to give informed consent, healthy participants/visitors of the AMC
Recruitment method: recruitment via treating physician via a folder. Travel cost will be reimbursed if visit cannot be combined with a regular visit. Personal bloodvalues can be given at the end of the study.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Inability to give informed consent
inability to follow instructions of the investigator
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL5931 |
| NTR-old | NTR6111 |
| CCMO | NL58755.018.16 |
| OMON | NL-OMON42857 |