Antibodies to the TSH receptor which are produces in Graves' disease can enhance T cell development.
ID
Bron
Aandoening
Immunodeficiencies
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Occurrence of thymic hyperplasia in patients with Graves' disease,
presence of thymic hyperplasia will be analysed with I123 scan 20min and
24hours after intake of I123.<br>
Outcomes will be compared with a database of healthy people, which is already present.
Achtergrond van het onderzoek
Graves' disease is associated with thymic hyperplasia. Since it is known
that the TSH receptor is also present in the thymus, stimulating
antibodies against the TSH receptor could play a role in thymic
hyperplasia. The aim of this study is to investigate how often thymic
hyperplasia is present in Graves' disease. Moreover we will investigate
if thymic hyperplasia in Graves' disease is caused by stimulation of T
cell development in the thymus. 30 patients with Graves' disease who
will be treated with radioactive iodine therapy will be recruited on the
nuclear medicine department. After the radioactive iodine scan according
to the regular treatment, an extra scan will be made from the thymus.
Moreover blood samples of these patients will be taken to analyse the t
cell pool.
Doel van het onderzoek
Antibodies to the TSH receptor which are produces in Graves' disease can enhance T cell development.
Onderzoeksopzet
T0 blood sample;
T1 scan 20 min after radioactive iodine;
T2 scan 24h after radioactive iodine.
Onderzoeksproduct en/of interventie
N/A
Publiek
Kim Weerd, van der
Rotterdam 3015 GE
The Netherlands
+31 (0)10 7044651
k.van.der.weerd@erasmusmc.nl
Wetenschappelijk
Kim Weerd, van der
Rotterdam 3015 GE
The Netherlands
+31 (0)10 7044651
k.van.der.weerd@erasmusmc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Graves' disease;
2. 18-40 years of age.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Use of corticosteroids last three months;
2. Infections during last three months;
3. Thymectomy;
4. Pregnancy;
5. Alcohol abuse.
Opzet
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL2018 |
| NTR-old | NTR2135 |
| CCMO | NL22657.078.08 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |
| OMON | NL-OMON35294 |