Greater age will be associated with a lower mitoVO2 and mitoPO2. Comorbidities likewise will be associated with a lower mitoVO2 and mitoPO2
ID
Bron
Verkorte titel
Aandoening
Diabetes Mellitus type II, Obesity, and Neurodegenerative diseases
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
- To investigate the association between age and mitoPO2 values
Achtergrond van het onderzoek
A new technique to measure mitochondrial oxygen tension was recently developed and calibrated by our lab. With this technique, mitochondrial oxygen tension ‘mitoPO2’ and mitochondrial oxygen consumption ‘mitoVO2’ can be measured in human skin. This led to the introduction of the COMET, an acronym of Cellular Oxygen METabolism (COMET, Photonics Healthcare B.V. Utrecht) which enables bed-side monitoring of mitoPO2 and mitoVO2 in real time. Previous studies have illustrated the potential of these measurements in various clinical conditions, unfortunately the influence of aging and chronic disease has not been examined. Before the COMET monitor can be used in clinical settings, it has to be known if these factors have any influence on the measurements. This study will therefore, examine the association between age and mitoPO2 and mitoVO2 values. Secondly, it will investigate whether there is any association between comorbidity and mitoPO2.mitoVO2. Lastly, the study will evaluate ifmitoPO2 and mitoVO2 values differ between measurement location namely, the upper arm or sternum. This is because measurement locations vary in different clinical settings.
Doel van het onderzoek
Greater age will be associated with a lower mitoVO2 and mitoPO2. Comorbidities likewise will be associated with a lower mitoVO2 and mitoPO2
Onderzoeksopzet
Measurement day
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Healthy Volunteers
- Aged ≥ 18 and ≤ 90 years old
- Acceptable proficiency of the Dutch language
- Healthy volunteers without physical or mental illness
Comorbidity group
- Aged ≥ 18 and ≤ 90 years old
- Acceptable proficiency of the Dutch language
- One of the underlying illnesses: neurodegenerative disease, diabetes mellitus type II
or obesity (BMI>30), no other relevant comorbidity
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Porphyria
- Known intolerance to components of the ALA plaster
- Presence of mitochondrial disease
- Pregnancy/lactation
- Patients with skin lesions on the measurement location which impede measurements
- Incapability to provide inform consent, due to a mental condition interfering with the ability to understand the provided information
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL9670 |
| CCMO | NL76685.078.21 |
| OMON | NL-OMON51166 |