Carcinoembryonic antigen (CEA) is used as a biomarker in colon carcinoma, however in patients with (non-)small cell lung cancer ((N)SCLC) increased serum CEA levels commonly found. Since decline of high CEA levels in colon carcinoma is predictive…
ID
Bron
Verkorte titel
Aandoening
(N)SCLC
Biomarker
CEA
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Correlation of CEA decline (when CEA initially is increased (>5.0 ng/mL)) and OR (conform RECIST 1.1 criteria).
Achtergrond van het onderzoek
Retrospective observational study to evaluate the association between changes in CEA levels and objective response (OR), overall survival (OS) and presence or occurance of brain metastasis during first-line conventional chemotherapy, targeted therapy or immunotherapy in patients with advanced (N)SCLC.
Doel van het onderzoek
Carcinoembryonic antigen (CEA) is used as a biomarker in colon carcinoma, however in patients with (non-)small cell lung cancer ((N)SCLC) increased serum CEA levels commonly found. Since decline of high CEA levels in colon carcinoma is predictive for objective response (OR), it is hypothesised that (N)SCLC is associated with increased CEA concentrations and decreases in CEA levels have prognostic value for therapy response.
Onderzoeksopzet
CEA levels prior to treatment (baseline), on week 3, 6 and 12.
Onderzoeksproduct en/of interventie
Retrospective observational study
Publiek
D. C. de Jong
Nieuwegein
The Netherlands
088-3207278
dc.de.jong@antoniusziekenhuis.nl
Wetenschappelijk
D. C. de Jong
Nieuwegein
The Netherlands
088-3207278
dc.de.jong@antoniusziekenhuis.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
I. Advanced (N)SCLC patients who received conventional chemotherapy, targeted therapy or immunotherapy between 2009-2016.
II. CEA levels available prior to treatment (baseline), on week 3, 6 and 12.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Subjects who do not meet inclusion criteria.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL5767 |
| NTR-old | NTR5921 |
| Ander register | MEC-U te Nieuwegein. : W16.042 |