A history of childhood trauma is associated with poorer neurocognitive function including social cognition impairments and more psychopathology in patients with first episode psychosis when compared to those without a history of childhood trauma.
ID
Bron
Aandoening
Psychosis/psychose
Childhood trauma/vroegkinderlijk trauma
Cognition/cognitie
Social cognition/sociale cognitie
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
1. Cognitive functioning (IQ, memory, attention, executive funtioning, social cognition)<br>
2. Severity of psychotic symptoms<br>
3. Childhood trauma
Achtergrond van het onderzoek
Rationale: A history of childhood trauma (CT) is a risk factor for the development of psychosis, with a dose-effect relationship. Not only do patients with a psychotic disorder (PD) more frequently report CT, a history of CT can also have a detrimental effect on the course and outcome of the psychotic disorder. Studies have shown that patients with a PD show cognitive impairments, even at the time of their first-psychotic episode. Even worse cognitive performances are seen when patients are diagnosed with both a PD and a posttraumatic stress disorder (PTSD). Many patients with PTSD have a history of CT. However, only a few studies examined the association between CT and neurocognition in patients with a PD and these showed inconclusive findings. The purpose of this study is to investigate this association in patients with a first-episode psychosis (FEP). We hypothesise that a history of CT is associated with poorer neurocognitive function including social cognition impairments and more psychopathology in patients with FEP when compared to those without a history of CT.
Objective: This study investigates the association between a history of CT, neurocognition and psychopathology in patients with FEP. In addition, we will explore gender or trauma type differences in this association.
Study design: The current study design is an observational cohort study. Standard clinical care (SCC) data, including a comprehensive cognitive assessment, a history of CT and psychopathological measures, will be collected from September until November 2019 from patients who have been diagnosed with a PD.
Study population: Patients between the age of 18 and 35 years, diagnosed with a PD with less than three years since treatment onset, will participate in the study. Every participant is in care in a first-episode psychosis mental health service team, of Yulius Mental Health. This study aims to include 49 patients.
Doel van het onderzoek
A history of childhood trauma is associated with poorer neurocognitive function including social cognition impairments and more psychopathology in patients with first episode psychosis when compared to those without a history of childhood trauma.
Onderzoeksopzet
This is a cross-sectional study. All measurements are done on one timepoint.
Onderzoeksproduct en/of interventie
No interventions.
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- diagnosed with a psychotic disorder according to the DSM-V with less than three years since treatment onset for psychotic symptoms
- age between 18 and 35 years
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- the participant is in an acute phase of the disorder, therefore not able to undergo the neurocognitive assessment,
-there is active substance dependence (other than tobacco or cannabis),
- there is a presence of a documented neurological condition (i.e. epilepsy) or a documented history of severe head trauma with loss of consciousness,
-the female participant is pregnant,
-there are learning disabilities (IQ<70), language difficulties or visual impairments that limit the cognitive assessment
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL7392 |
| NTR-old | NTR7600 |
| Ander register | Toetsingscommissie Wetenschappelijk Onderzoek Rotterdam : 2017-61 |