A disruption of the biological clock is presumed in hemodialysis patients since they frequently suffer from sleep problems and lack a nocturnal melatonin surge, which is a reasonable readout for disturbed clock performance. The origin of these…
ID
Bron
Verkorte titel
Aandoening
hemodialysis
(disturbed) circadian rhythm
Ondersteuning
Leo Fretz Stichting
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Establish 24-hr peripheral clock gene and clock controlled output gene expression profiles in blood of hemodialysis patients compared to control subjects to diagnose renal disease mediated circadian disruption.
Achtergrond van het onderzoek
N/A
Doel van het onderzoek
A disruption of the biological clock is presumed in hemodialysis patients since they frequently suffer from sleep problems and lack a nocturnal melatonin surge, which is a reasonable readout for disturbed clock performance. The origin of these clinically observed disturbances is still unknown. Possibly, there is an underlying disturbed peripheral clock synchronization by constitutively high (rather than oscillating) amounts of humoral clock-resetting compounds.
Onderzoeksopzet
24h-blood sampling:
9:00, 13:00, 17:00, 21:00, 01:00, 05:00, 09:00.
Sleep measurement (actigraphy): 4 days + nights.
Onderzoeksproduct en/of interventie
N/A
Publiek
dept. Hospital Pharmacy<br>
PO Box 1502
M. Russcher
Amersfoort 3800 BM
The Netherlands
+31 (0)33 8501720
M.Russcher@meandermc.nl
Wetenschappelijk
dept. Hospital Pharmacy<br>
PO Box 1502
M. Russcher
Amersfoort 3800 BM
The Netherlands
+31 (0)33 8501720
M.Russcher@meandermc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Hemodialysis patients:
1. Stable chronic hemodialysis patients;
2. Written informed consent;
3. Age 18-85 years;
4. Good understanding of Dutch language.
Control patients:
1. Stable patients;
2. MDRD-GFR > 60 ml/min;
3. Age and gender matched with hemodialysis patient;
4. Written informed consent;
5. Age 18-85 years;
6. Good understanding of Dutch language.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Blindness;
2. Fever >38ºC;
3. CRP > 20 mg/L;
4. Use of hypnotics during study period;
5. Anesthesia within 48 hours prior to start study measurements;
6. Serious co-morbidity that prevents participation in this study according to the investigators (e.g. neurological, psychiatric, blindness, angina, heart failure NYHA class IV).
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL3338 |
| NTR-old | NTR3631 |
| Ander register | VCMO / CCMO : R12.010 / NL39856.100.12; |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |