cycling from hypoThyroidism to Hyperthyroidism during Early treatment of differentiated Thyroid carcinomA

The subject has a histologically confirmed diagnosis of DTC.

The subject is at least 18 years old.

The subject has written informed consent

The subject is mentally competent (according to the criteria mentioned in ¡¥WGBO boek 2, bijlage 9¡¦)

„h The subject is 75 years or older.

„h The subject will receive treatment with rhTSH before radioiodine ablation therapy.

„h The subject has a history of severe lung disease (COPD gold class III or worse).

„h The subject has a history of cerebrovascular or coronary events.

„h The subject has a history of atrial fibrillation.

„h The subject has a history of heart failure NYHA class III or worse.

„h The subject has a severe limited physical strain (NYHA class IV)

„h The subject is unable or not willing to sign informed consent.

„h The subject is pregnant

„h The subject has contra-indications for MRI, defined as severe claustrophobia, having an implantable cardioverter-defibrillator, known allergy for gadolinium, known renal dysfunction with eGFR <30, treated with haemodialysis, or body weight >200 kg.

For the secondary objective cholesterol function and balance, subjects who meets any of the following criteria will be excluded from participation in this sub-study.

„h The subject uses lipid lowering medication

„h The subjects uses laxatives

For subjects participating in the baseline measurements:

„h The subject uses thyroid hormone medication