The tolerance to RISA root canal fluid determined in an in-vivo study

-- apical periodontitis has been diagnosed and confirmed with an intra-oral radiograph and appears on the radiograph as a radiolucent area around one or more root tips of the affected tooth. A root canal treatment has a reasonable/good prognosis (Sjögren et al. 1990) and the subject prefers NSRCT over tooth extraction or monitoring. The affected tooth has not previously received a complete root canal treatment.

- no spontaneous pre-operative pain or spontaneous pre-operative pain less than 36 (see fig. 1) (Heft & Parker 1984)

- no or mild swelling and no draining sinus tract on affected tooth.

- 18 – 75 years.

- completed the medical history questionnaire.

- 1st or 2nd molar, 1st or 2nd premolar

- DPSI of subject tooth is ≤3-

- tooth mobility ≤1

- signed the informed consent form

- pain >36 on Heft-Parker VAS scale (fig. 1)

- subject tooth with a mobility score 2 or more

- subject tooth with a DPSI ≥3+

- subject tooth with open or incompletely formed root apices

- subject tooth that requires a post

- subject tooth with a vertical fracture or horizontal fracture extending below the cemento-enamel junction of the tooth

- teeth in the same quadrant requiring root canal therapy

- teeth with hypersensitive dentine in the same left or right facial half

- absence of a periapical

- previous (non)surgical (root-canal) treatment on subject tooth

- draining sinus tract or exacerbation originating from affected tooth



Current medication related criteria:

- chronic use of pain relief medication

- (par)enteral use of bisphosphonates

- systemic corticoid therapy



General-health related criteria:

- non-odontogenic facial pain

- any known infectious diseases (eg, human immunodeficiency virus, hepatitis B, hepatitis C, tuberculosis, or prion-induced disease)

- history of cancer in the oral-maxillofacial region

- history of cancer in the last two years

- history of head and/or neck radiation therapy

- diabetes mellitus type I/II,

- chronic inflammatory diseases like morbus Crohn or rheumatoid arthritis

- known sensitization to sorbic acid and its salts

- pain >36 on Heft-Parker VAS scale (fig. 1)

- subject tooth with a mobility score 2 or more

- subject tooth with a DPSI ≥3+

- subject tooth with open or incompletely formed root apices

- subject tooth that requires a post

- subject tooth with a vertical fracture or horizontal fracture extending below the cemento-enamel junction of the tooth

- teeth in the same quadrant requiring root canal therapy

- teeth with hypersensitive dentine in the same left or right facial half

- absence of a periapical

- previous (non)surgical (root-canal) treatment on subject tooth

- draining sinus tract or exacerbation originating from affected tooth