The effects of the inflammatory response to a surgical procedure on postoperative cognitive decline in elderly cancer patients will be investigated. Preoperative inflammation level, muscle strength, nutritional status and general functioning will be…
ID
Bron
Verkorte titel
Aandoening
Older adults, postoperative cognitive decline, functional decline, inflammatory response, onco-geriatric patients, surgery
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
A change in cognitive functioning at two weeks, three months and one year postoperatively as measured by the Ruff Figural Fluency Test, Trailmaking Test and Rey's verbal learning test in comparison to the preoperative scores.
Achtergrond van het onderzoek
Onco-geriatric surgical patients are at an increased risk of postoperative complications. Especially postoperative cognitive impairment has an enormous impact on quality of life and daily functioning in this population.
An inflammatory response to surgery seems to be related to the development of postoperative cognitive decline, delirium and other postoperative complications.
The aim of this study is to investigate the effects of this inflammatory response and identify predictors and possible confounders like preoperative inflammation level, muscle strength, nutritional status and general functioning on this effect.
Doel van het onderzoek
The effects of the inflammatory response to a surgical procedure on postoperative cognitive decline in elderly cancer patients will be investigated. Preoperative inflammation level, muscle strength, nutritional status and general functioning will be investigated as possible confounders of postoperative impairment.
Onderzoeksopzet
preoperatively, at hospital discharge or two weeks postoperatively and three months and one year postoperatively
Onderzoeksproduct en/of interventie
Not applicable
Publiek
P.O. Box 30.001
B.L. Leeuwen, van
Groningen 9700 RB
The Netherlands
+31 (0)50 3612301
blvleeuwen@hetnet
Wetenschappelijk
P.O. Box 30.001
B.L. Leeuwen, van
Groningen 9700 RB
The Netherlands
+31 (0)50 3612301
blvleeuwen@hetnet
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
• surgery is scheduled more than 24 hours after inclusion in the study as we feel this is the time necessary to obtain test results and plan the intraoperative recording of data.
• surgery under general, local or regional anaesthesia.
• written informed consent given according to local regulations.
• Patients can only be included in this trial once.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
• any physical condition potentially hampering compliance with the study protocol and follow-up schedule, this includes: severe visual impairment, total deafness or the inability to hold a pencil
• personal time constraints unabling patients to comply to the study protocol
• patients unable to comply with the outcome questionnaires (this includes insufficient knowledge of the Dutch language)
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL4441 |
| NTR-old | NTR4564 |
| Ander register | : METc2014/095 |