we hypothesize that translocation of Gram- negative intestinal bacteria is associated with changes in (small) intestinal microbiota composition and can be influenced by fecal microbiota transplantation.
ID
Bron
Verkorte titel
Aandoening
metabolic syndrome, diabetes mellitus
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
changes in postprandial translocation of intestinal bacteria between donor and own ecal transplantation.
Achtergrond van het onderzoek
A relation exists between gutmicrobiota composition, plasma bacterial composition as well as adpose tissue bacterial signatures. We will thus study whether changes in gutmicrobiota composition using fecal transplantation affects bacterial signature in periferpheral tissue (blood/adipose tissue)
Doel van het onderzoek
we hypothesize that translocation of Gram- negative intestinal bacteria is associated with changes in (small) intestinal microbiota composition and can be influenced by fecal microbiota transplantation.
Onderzoeksopzet
0 and 3/4 weeks
Onderzoeksproduct en/of interventie
fecal transplantation
Publiek
MEIBERGDREEF 9, KAMER F4.159.2
M. Nieuwdorp
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5666612
m.nieuwdorp@amc.uva.nl
Wetenschappelijk
MEIBERGDREEF 9, KAMER F4.159.2
M. Nieuwdorp
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5666612
m.nieuwdorp@amc.uva.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
• Male sex
• Caucasian
• BMI >25 kg/m2
• At least 3 out of 5 NCEP metabolic syndrome criteria: fasting plasma glucose ≥5.6
mmol/l, triglycerides ≥1.7 mmol/l, waist-circumference >102 cm, HDL-cholesterol 1.04
mmol/l, blood pressure ≥130/85 mmHg
• Scheduled for laparoscopic cholecystectomy or laparascopic gastric bypass
• able to give informed consent
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
• A history of cardiovascular event (CVA, MI or pacemaker implantation)
• Use of any medication including PPI and antibiotics in the past three months
• (Expected) prolonged compromised immunity (due to recent cytotoxic chemotherapy
or HIV infection with a CD4 count < 240/mm3)
• Presence of overt T2D
• Smoking
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL4894 |
| NTR-old | NTR5141 |
| Ander register | METC : 2015_014 |