We envision that a standardized follow-up framework designed to better monitor pulmonary health in moderate-late preterm infants will reduce respiratory disease and related healthcare consumption. The identification and preventive treatment of…
ID
Bron
Verkorte titel
Aandoening
Prematurity, Wheezing, Respiratory Tract Infections
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Total number of physician diagnosed lower RTI and wheezing episodes in the first 18 months of life.
Achtergrond van het onderzoek
Rationale: Approximately 8% of all births occur between 30-36 weeks of pregnancy (‘moderate-late’ prematurity) and is associated with the development of chronic obstructive lung disease later in life. Respiratory tract infections (RTI) and wheezing illnesses disproportionally affect preterms in early life resulting in frequent hospitalisation. Besides prematurity, several other modifiable influencing factors are associated with impaired pulmonary development: respiratory tract infections (RTI), local air pollution, tobacco smoke exposition, vitamin D deficiency, maternal stress and antibiotic usage.
Objectives: To identify and treat modifiable influencing factors negatively affecting pulmonary health in moderate-late preterms during the first 18 months of life using an innovative multidisciplinary follow-up framework.
Doel van het onderzoek
We envision that a standardized follow-up framework designed to better monitor pulmonary health in moderate-late preterm infants will reduce respiratory disease and related healthcare consumption. The identification and preventive treatment of modifiable influencing factors and early detection of abnormal pulmonary function in a unique follow-up framework will substantially improve pulmonary health and prevent suboptimal pulmonary development.
Onderzoeksopzet
T 3,6,12 and 18 months
Onderzoeksproduct en/of interventie
LONG LOVE Framework
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
• Gestational age at delivery between 30+0 and 35+6 weeks
• Written informed consent by both parents or formal caregivers
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
• Underlying other severe respiratory disease such as broncho-pulmonary dysplasia (unexpected in this group) ; diaphragmatic hernia; other serious congenital lung disorders; hemodynamic significant cardiac disease; immunodeficiency; severe failure to thrive; birth asphyxia with predicted poor neurological outcome; syndromic or serious congenital disorders.
• Parents unable to speak and read the Dutch or English language
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
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| Register | ID |
|---|---|
| NTR-new | NL9688 |
| Ander register | METC MEC-U : XXXXXXXXXXXX |