Supplementation of infant formula with a combination of pre- and probiotics may protect infants against infectious complications such as diarrhoea and respiratory infections. We speculate that the combination of pre and probiotics is better…
ID
Bron
Verkorte titel
Aandoening
Heathy term infants with intercurrent diseases: diarrhoea and respiratory infections.
Ondersteuning
Global Development Centre
P.Stuyvesantweg 1
Leeuwarden
8937 AC
Netherlands
rob.tebiesebeke@frieslandfoods.com
Performer: Dr Diny van Zoeren-Grobben
Isala Clinics
Neonatal Unit
Dr van Heesweg 2
Zwolle
8025 AB
Netherlands
Tel: *31-38-4247073
Fax: *31-38-4247667
Email: d.van.zoeren@isala.nl
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
- Frequency, incidence and duration of diarrhoea and respiratory infections
composition of gut flora
Achtergrond van het onderzoek
We speculate that the combination of pre and probiotics is better protective than only one of these substances. Supplementation of the combination of pre- and probiotics may reduce the incidence of infections to the same level as human milk fed infants.
Supplementation of infant formula with a combination of pre- and probiotics may protect infants against infectious complications such as diarrhoea and respiratory infections.
Doel van het onderzoek
Supplementation of infant formula with a combination of pre- and probiotics may protect infants against infectious complications such as diarrhoea and respiratory infections. We speculate that the combination of pre and probiotics is better protective than only one of these substances. Supplementation of the combination of pre- and probiotics may reduce the incidence of infections to the same level as human milk fed infants.
Onderzoeksopzet
1 - Frequency, incidence and duration of diarrhoea and respiratory infections, feeding tolerance : 2 weekly
2 - Antropometry: t=0, T = 3 and T=6 mths
3 - Fecal samples: T=0, T=3 and T=6 months
Onderzoeksproduct en/of interventie
Supplementation of infant formula with an combination of pre- and probiotics.
Publiek
Pieter Stuyvesantweg 1
R. Biesebeke, te
Leeuwarden 8937 AC
The Netherlands
++31612504012
rob.tebiesebeke@frieslandfoods.com
Wetenschappelijk
Pieter Stuyvesantweg 1
R. Biesebeke, te
Leeuwarden 8937 AC
The Netherlands
++31612504012
rob.tebiesebeke@frieslandfoods.com
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Healthy term infants with a postmenstrual age of 37-42 weeks
2. Birth weight between P10 and P90
3. Informed consent of both parents
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Neonatal sepsis
2. Severe congenital malformations
3. Birth asphyxia (apgar < 6 at 5 minutes, and/or umbilical cord pH < 7.00 and/or necessity of reanimation)
4. Admission to a pediatric ward
5. No Dutch or English speaking parents
6. Antibiotics to the mother during labour
7. Antibiotics to the infant in the first week of life
8. History of allergy with parents or sibs
Opzet
Deelname
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Andere (mogelijk minder actuele) registraties in dit register
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL1442 |
| NTR-old | NTR1503 |
| Ander register | : 06-1178 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd |
Samenvatting resultaten
2) Effect of supplementation of of infant formula with a a combination of pre- and probiotics on the composition of gut flora.