We hypothesize that intensive aerobic exercise in sedentary PD patients results in clinically relevant improvements of several disease-related symptoms.
ID
Bron
Aandoening
Parkinson's disease - Ziekte van Parkinson
Exercise - Bewegen
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
UPDRS-motor score after six months
Doel van het onderzoek
We hypothesize that intensive aerobic exercise in sedentary PD patients results in clinically relevant improvements of several disease-related symptoms.
Onderzoeksopzet
Assessments at baseline and after 6 months
Onderzoeksproduct en/of interventie
Aerobic exercise, exergaming; 3-5x/wk for 6 months
Publiek
Radboud University Medical Center
PO Box 9101
N.M. Kolk, van der
Nijmegen 6500 HB
The Netherlands
+31-24-3616600
nicolien.vanderkolk@radboudumc.nl
Wetenschappelijk
Radboud University Medical Center
PO Box 9101
N.M. Kolk, van der
Nijmegen 6500 HB
The Netherlands
+31-24-3616600
nicolien.vanderkolk@radboudumc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1) Idiopathic Parkinson’s disease, according to the UK Brain Bank criteria, diagnosed by a neurologist
2) H&Y stage ≤2
3) Age 30-75 years
4) Sedentary lifestyle (insufficient aerobic physical activity, as defined by the current American College of Sports Medicine (ACSM) recommendations for older adults23).
5) Both medicated and unmedicated patients are eligible, if they:
Receive a stable dopaminergic medication dose (both levo-dopa and/or a dopamine agonist are allowed) for one month before the study
Are umedicated and deemed unlikely to start treatment within the next month by their treating neurologist
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1) Use of beta-blockers
2) Use of anti-psychotics
3) Inability to cycle or perform stretching exercises due to (other) neurologic or orthopedic co-morbidities
4) Inability to fill out questionnaires or perform a computer task (i.e due to poor vision, inability to read Dutch (illiteracy or foreign language)
5) Psychiatric diseases, including major depressive disorder, severe or moderate depressive episode or any form of psychosis, diagnosed by a psychiatrist in the last year.
6) No internet at home
7) MMSE <24
8) Contra-indications for aerobic exercise including diagnosed cardiac diseases (for instance but not exclusive: unstable angina, heart block, arrhythmia’s, uncontrolled hypertension), diagnosed but poorly controlled diabetes mellitus or pulmonary diseases (e.g. but not exclusive COPD, exertional asthma, pulmonary emphysema).
9) Unavailable for more than 10% (approximately 2.5 weeks) of the 6 months
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
Register | ID |
---|---|
NTR-new | NL4575 |
NTR-old | NTR4743 |
CCMO | NL47747.091.14 |
OMON | NL-OMON44535 |