we hypothesize that there is a link between gut microbiota composition and development of venous thrombosis.
ID
Bron
Verkorte titel
Aandoening
subject with suspected Deep Venous Thrombosis (DVT)
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Changes in fecal flora/gutmicrobiota (HITCHIP see Qin Nature 2010) analysis of 1200 known intestinal bacteria in subjects with DVT vs subjects with a clinical suspicion of DVT but the absence of this diagnosis.
Achtergrond van het onderzoek
Despite the fact that many risk factors for venous thromboembolism have been established, 50% of these patients still present with idiopathic thrombosis. It has also been shown that endothelial glycocalyx plays an important role in maintaining coagulation factors in plasma, however the pathophysiological effects has never been elucidated. Older literature indicated a role for gram negative gut bacteria on coagulation (crucial for synthesis of clotting factors II, VII, IX and X), yet the effect of the gut microbiota in relation to endothelial glycocalyx on thrombotic tone has never been studied. In this study we will investigate whether there is a link between gut bacteria composition and DVT and whether this is mediated via impaired endothelial glycocalyx.
Doel van het onderzoek
we hypothesize that there is a link between gut microbiota composition and development of venous thrombosis.
Onderzoeksopzet
1. Baseline;
2. 3 monts after start acenocoumarol;
3. 2 months after cessation of acenocoumarol.
Onderzoeksproduct en/of interventie
Acenocoumarol in subjects with proven DVT according to current guidelines.
Publiek
MEIBERGDREEF 9, KAMER F4.159.2
M. Nieuwdorp
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5666612
m.nieuwdorp@amc.uva.nl
Wetenschappelijk
MEIBERGDREEF 9, KAMER F4.159.2
M. Nieuwdorp
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5666612
m.nieuwdorp@amc.uva.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Males or postmenopausal females;
2. Age between 18 and 60 years;
3. Suspicion of DVT at time of inclusion;
4. Written informed consent for future evaluation at time of diagnosis;
5. Fasted (no meal, coffee or tea) for at least 3 hours.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Smoking > 5 sig/day;
2. Premenopauzal females (due to hormonal changes);
3. Patients any medication including oral antionceptives and PPIs;
4. Use of antibiotics in last 3 months.
Opzet
Deelname
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| Register | ID |
|---|---|
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