The behavioural effects of an antihistamine is apparent in the evening after an evening dose, but will be smaller in the morning after a morning dose condition due to the excessive release of histamine shortly after awaking.
ID
Bron
Verkorte titel
Aandoening
Sedation / sedatie
Antihistamines / antihistaminica
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The Mean Absolute Tracking Error (mm) of the Divided Attention Task.
Achtergrond van het onderzoek
The mechanism responsible for the reversion of sedative effects caused by antihistamines might be mediated by restoring the balance between histamine release and synthesis after sleep. This would mean that histamine availability will be greatest shrotly after awakening. Because of that, the antihistamine will have less binding potential during that time compared to other times of administration. This study focuses therefore on the time-depending effects of the antihistamine hydroxyzine on cognition.
Doel van het onderzoek
The behavioural effects of an antihistamine is apparent in the evening after an evening dose, but will be smaller in the morning after a morning dose condition due to the excessive release of histamine shortly after awaking.
Onderzoeksopzet
Three testperiods of each an evening, a night and the morning after.
Onderzoeksproduct en/of interventie
1. Hydroxyzine 50 mg;
2. Placebo.
Publiek
Dept of Neuropsychology & Psychopharmacology, Faculty of Psychology and Neuroscience,
P.O. Box 616
J.G. Ramaekers
Maastricht 6200 MD
The Netherlands
+31 (0)43 3881951
J.Ramaekers@psychology.unimaas.nl
Wetenschappelijk
Dept of Neuropsychology & Psychopharmacology, Faculty of Psychology and Neuroscience,
P.O. Box 616
J.G. Ramaekers
Maastricht 6200 MD
The Netherlands
+31 (0)43 3881951
J.Ramaekers@psychology.unimaas.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Aged between 18 and 45 years;
2. Healthy volunteers;
3. BMI between 19 and 30;
4. Able to give a written informed consent;
5. Able to understand the protocol and to come to the visits;
6. Use of a contraceptive method (for women).
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Medical history of major medical, psychiatric illness or surgery which, in the judgement of the investigator, could jeopardize their health or is likely to modify their handling of the study drug;
2. Any non corrected visual defect or locomotor disorder which could interfere with the study;
3. Acute or chronic systemic disease or disorder;
4. History of hypersensitivity to H1 antihistamines, benzimidazoles or lactose;
5. Seasonal allergic rhinitis or urticaria treated by antihistamine;
6. History of alcohol or drug abuse.
Opzet
Deelname
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|---|---|
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