The peripheral immune response is changed following a traumatic spinal cord injury.
ID
Bron
Verkorte titel
Aandoening
Spinal cord injury
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
- Identification of the autoantibodies produced after SCI.
- Characterisation of the autoantibody response after SCI in patients over time.
- Assessment of the association between clinical outcome parameters and changes in antibody levels: determining the prognostic biomarker potential of the candidate biomarkers.
Achtergrond van het onderzoek
This project focuses on the characterization of the immune response following a traumatic SCI. As individual components of the immune response work in close collaboration and have a strong influence on each other, it is important to obtain a very detailed and elaborate overview of the immune response. Therefore we will examine different aspects of the immune response in this project. Hereby, autoantibodies, immune cell populations, immune components, inflammatory and neurodegeneration markers will be investigated.
Doel van het onderzoek
The peripheral immune response is changed following a traumatic spinal cord injury.
Onderzoeksopzet
1. Admission in the rehabilitation center
2. 3 weeks after spinal cord injury (SCI)
3. 6 weeks after SCI
4. 12 weeks after SCI
5. 6 months after SCI
6. 1 year after SCI
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- Individuals older than 18 years
- Diagnosis of spinal cord injury.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Individuals with pre-existing autoimmune diseases
- Use of anti-inflammatory or immune modulatory treatment.
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL8803 |
| Ander register | METC azM/UM : not known yet |