Lowering of daily carbohydrate intake by 10% of total energy intake and isocaloric replacement by protein intake during 4 weeks will significantly reduce office and ambulatory blood pressure in overweight subjects with prehypertension or grade 1…
ID
Bron
Verkorte titel
Aandoening
high blood pressure, overweight, dietary proteins and carbohydrates
hoge bloeddruk, overgewicht, voedingseiwitten en -koolhydraten
Ondersteuning
Maastricht University
Maastricht
The Netherlands
Wageningen
The Netherlands
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Change in office and 24-h ambulatory blood pressure after 4 weeks intervention
Achtergrond van het onderzoek
This trial will investigate the blood pressure lowering effect of dietary proteins and explore its underlying mechanism of action.
Doel van het onderzoek
Lowering of daily carbohydrate intake by 10% of total energy intake and isocaloric replacement by protein intake during 4 weeks will significantly reduce office and ambulatory blood pressure in overweight subjects with prehypertension or grade 1 hypertension.
Onderzoeksopzet
Baseline, 4 weeks intervention
Onderzoeksproduct en/of interventie
Carbohydrate (maltodextrine) supplementation vs protein (mixture of dietary proteins) supplementation, 10% of total energy intake, isocaloric
Publiek
Department of Human Biology
P.O. Box 616
M.A. Baak, van
Maastricht 6200 MD
The Netherlands
+31 (0)43 3881630
m.vanbaak@hb.unimaas.nl
Wetenschappelijk
Department of Human Biology
P.O. Box 616
M.A. Baak, van
Maastricht 6200 MD
The Netherlands
+31 (0)43 3881630
m.vanbaak@hb.unimaas.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Men and women
2. BMI 25-30 kg/m2
3. High normal or untreated grade 1 hypertension (systolic blood pressure 130-159 mmHg, diastolic blood pressure 85-99 mmHg)
4. Age 20-65 years
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Smokers
2. Food allergies
3. Unwillingness to stop use of dietary supplements (except those provided in the study)
4. Use of prescription medication
5. Recent history of or current dieting
6. Gastrointestinal problems
7. Plasma creatinine < 60 mmol/L
8. Presence of urinary protein (stick test)
9. Fasting glucose > 7 mmol/L
10. At randomisation: average blood pressure of visits 1 and 2 outside inclusion range for blood pressure
Opzet
Deelname
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