1. Methylphenidate (MPH) increases activation in task relevant areas and task performance 2. Hydrocortisone (HC) increases activation in task relevant areas and task performance 3. MPH + HC increase activation in task relevant areas, but might…
ID
Bron
Verkorte titel
Aandoening
addiction
relapse
stress
recreational drug users
healthy controls
Ondersteuning
Alexander von Humboldt Foundation
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
-imaging results under the influence of a psychostimulant, a
stress hormone or both.
Doel van het onderzoek
1. Methylphenidate (MPH) increases activation in task relevant areas and task performance
2. Hydrocortisone (HC) increases activation in task relevant areas and task performance
3. MPH + HC increase activation in task relevant areas, but might impair task performance in healthy controls and improve in recreational drug users
Onderzoeksopzet
Day 1, day 8, day 15, day 22
Onderzoeksproduct en/of interventie
1.placebo
2. methylphenidate
3. hydrocortisone
4. methylphenidate + hydrocortisone
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
-bloodscreen (normal level)
-thyroidal parameters (normal level)
-ECG (normal level)
-negative drugscreen in urine (Benzodiazepine, Opiate, Amphetamine,
Cannabis).
-no nephrological or thyroidal diseases in medical history
-no metal in the human body
-no tattoos
-age between 18 and 40 years
-Body Mass Index (BMI) between 18 und 28
-no first degree relatives with psychiatric disorders in medical history
-no psychiatric or neurological disorders in medical history
-righthandedness
-native German speakers
For women: negative pregnancy test
For recreational drug users: experience with psychostimulants
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
-volunteers who are unable to sign the informed consent
-pregnancy
-volunteers under the age of 18 years
-magnetic metal implants, contraceptive coil, tattoos
-colorblindness
For recreational drug users: drug addiction or dependence in medical
history
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL4919 |
| NTR-old | NTR5021 |
| Ander register | 2012-005284-27 : EK 019/15 |