Timing of antibiotic administration during a cesarean section (prior to the cesarean section versus after clamping the cord) has a significant influence on the diversity of the developing neonatal intestinal microbiota and presence of specific…
ID
Bron
Verkorte titel
Aandoening
Cesarean section, keizersnede
Vaginal delivery, vaginale partus
Intestinal colonization, intestinal kolonisatie
Microbiota, microbioom
Antibiotics, antibiotica
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
ƒ{1. To describe and compare intestinal microbiome colonisation (by means of IS-pro) of neonates born by cesarean section, in terms of timimng of antibiotics treatment: prior to caesarean section (NVOG protocol) or after clamping of the umbilical cord (currently used protocol).
Doel van het onderzoek
Timing of antibiotic administration during a cesarean section (prior to the cesarean section versus after clamping the cord) has a significant influence on the diversity of the developing neonatal intestinal microbiota and presence of specific bacterial species.
Onderzoeksopzet
- Postnatal age 0 (day of birth)
- Postnatal age 7 days
- Postnatal age 28 days
Onderzoeksproduct en/of interventie
- 20 women will be treated according the current protocol on antibiotic administration (antibiotic administration after clampsing of the umbilical cord);
- 20 women will be treated according to the NVOG protocol (administration of antibiotics just prior to skin incision)
- 20 women admitted for outpatient vaginal delivery will be asked to participate in this study (providing baseline characteristics)
From each participating woman, one rectal swab and one vaginal swab will be collected closely prior to delivery.
Directly after delivery, oneoral swab will be collected from the neonate. In addition, neonatal fecal samples will be collected on the 1st, 7th and 28th day after birth. Antibiotic levels will be determined from the umbilical cord blood from women assigned to the antibiotic administration prior to skin incision
Publiek
P.O. Box 7057
J.I.P. Vries, de
Amsterdam 1007 MB
The Netherlands
JIP.deVries@VUMC.nl
Wetenschappelijk
P.O. Box 7057
J.I.P. Vries, de
Amsterdam 1007 MB
The Netherlands
JIP.deVries@VUMC.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Mother:
- Delivery at a gestational age > 36+6 weeks
- Vaginal or primary cesarean delivery
- Written informed consent
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Mother:
- Age < 18 years
- Antibiotic use during pregnancy
- Usage of immunosuppresive drugs up to 3 months prior to delivery
- BMI > 30
- Inflammatory bowel diseases, celiac disease
- Major gastro-intestinal operation in the past (e.g. bowel resection, gastric bypass)
- Diabetes mellitus type1 and 2, and gestational diabetes mellitus insuline dependent)
- intoxications (smoking, alcohol or drugs)
Exclusion after delivery
Mother
- Antibiotic use during first month
Neonate
- Antibiotic use during first month
- Usage of immunosuppresive drugs during first month
- Congenital gastro-intestinal disease
- Gastro-intestinal operation during first month
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL5845 |
| NTR-old | NTR6000 |
| Ander register | : 2014.468 |