Anesthesia exposure before the age of 12 months old has a negative impact on neurocognitive development.
ID
Bron
Verkorte titel
Aandoening
Surgeries related to dDuodenal-jejunal-ileal atresia repairs, anorectal malformation, Hirschsprung disease and/or inguinal hernia
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Neurocognitive development as measured using eye-tracking metrics
Achtergrond van het onderzoek
Recent evidence indicates that prolonged or repeated anesthesia threaten neurodevelopment. Therefore, we deem that it is crucial to assess the impact of different levels of anesthesia exposure between groups on neurodevelopmental outcome. For this prospective study, children with and without a history of general anesthesia exposure during pediatric surgery are recruited at the age of 12 months to measure neurodevelopment at the outpatient clinic using the Ages & Stages Questionnaire, the Bayley Scales of Infant Development and the Eye-tracking paradigms.
Doel van het onderzoek
Anesthesia exposure before the age of 12 months old has a negative impact on neurocognitive development.
Onderzoeksopzet
Participation in this trial consists of one (extra) visit to the outpatient clinic. For most patients, this will be scheduled during their regular follow-up visit at 12 months (± four weeks) of age.
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
In order to be eligible to participate in this study, a subject must meet all of the following criteria: age 12 months (± four weeks) with a history of general anesthesia exposure (patient group) or without a history of general anesthesia (healthy controls)
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Children with comorbid conditions affecting structure and/or function of the central nervous system (e.g. premature birth) will be excluded from participation in this study.
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL8937 |
| Ander register | METc Amsterdam UMC, location AMC : METC 2019_249 |