We hypothesize that the hypothalamic neuronal activity in response to water is different in response to a mixed meal.
ID
Bron
Verkorte titel
Aandoening
diabetes
suikerziekte
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Hypothalamic neuronal activity as measured with FMRI.
Achtergrond van het onderzoek
It has long been recognized that the hypothalamus plays a crucial role in metabolism. It is thought that the hypothalamus and brain stem get input from the periphery about the available food sources and that, thereafter, efferent neuroendocrine systems come in action to regulate food intake.
Several groups have focused on the effect of glucose ingestion on blood oxygen level-dependent (BOLD) signals in the hypothalamus (detected by MRI). Although there have been some contradicting papers, most studies found that the BOLD signal is diminished after the ingestion of glucose.
In future studies it would be more elegant to study the effects of a mixed meal on hypothalamic neuronal activity (before and after interventions), since this resembles the physiological stimulus (food) more closely. Thus far, the effects of a mixed meal on hypothalamic neuronal activity as measured by fMRI (BOLD) have not been established. Therefore, we will study the effects of a mixed meal versus water on hypothalamic neuronal activity.
Doel van het onderzoek
We hypothesize that the hypothalamic neuronal activity in response to water is different in response to a mixed meal.
Onderzoeksopzet
Start date 20-01-2009.
Onderzoeksproduct en/of interventie
Drinking nutridrink or water while a FMRI is being made.
Publiek
Leiden University Medical Center
Dept of Endocrinology and Metabolism, C4-67
Albinusdreef 2
Leiden 2333 ZA
The Netherlands
+31715265304
m.a.wijngaarden@lumc.nl
Wetenschappelijk
Leiden University Medical Center
Dept of Endocrinology and Metabolism, C4-67
Albinusdreef 2
Leiden 2333 ZA
The Netherlands
+31715265304
m.a.wijngaarden@lumc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Healthy males;
2. Age 19-29;
3. BMI 19-25 kg/m2;
4. Stable weight for the last 2 years;
5. Caucasian;
6. No family history of DM2.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Use of medication known to affect glucose metabolism (for example prednison) or lipid metabolism;
2. History of genetic or psychiatric disease (e.g. fragile X syndrome, major depression) that affects the brain;
3. Significant chronic disease;
4. Galactosemia;
5. Renal or hepatic disease;
6. Recent weight changes or attempts to lose or gain weight (> 3 kg weight gain or loss, within the last 3 months);
7. Smoking (current);
8. Alcohol consumption of more than 28 units per week at present or in the past;
9. Recent blood donation (within the last 3 months);
10. Contra-indication to MRI scanning:
A. Claustrophobia;
B. Pacemakers and defibrillators;
C. Nerve stimulators;
D. Intracranial clips;
E. Intraorbital or intraocular metallic fragments;
F. Cochlear implants;
E. Ferromagnetic implants.
Opzet
Deelname
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