iFABP can be used as a primary diagnostic tool to detect and exclude mesenteric ischemia.
ID
Bron
Verkorte titel
Aandoening
mesenteric ischemia
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
I-FABP concentraties in blood and urine compared with result of CT-angiography and surgery.
Achtergrond van het onderzoek
Mesenteric ischemia is a potentially lethal condition in which early diagnosis is pivotal. Since simple and readily available diagnostic tools are lacking, mesenteric ischemia is still accompanied with a high morbidity and mortality.
CT-angiography is the golden standard to assess acute mesenteric ischemia with a good sensitivity and good specificity. However, a CT-angiography is associated with important disadvantages for the patient and since the early presentation may be atypical, a CT-angiography is often performed at a later stage of the disease. Intestinal-Fatty Acid Binding Protein (I-FABP) is a cytosolic protein that resides in the intestinal epithelial cell en is detectable in urine and blood during intestinal ischemia. In previous experimental and clinical studies has been shown that iFABP values in blood and urine strongly correlate with intestinal damage and ischemia. In this study we will investigate whether iFABP can be used as a primary diagnostic tool to detect and exclude mesenteric ischemia. I-FABP concentrations in plasma will be correlated to the results of CT-angiography and/ or surgery in a multicentre setting.
Doel van het onderzoek
iFABP can be used as a primary diagnostic tool to detect and exclude mesenteric ischemia.
Onderzoeksopzet
Day of presentation (0);
Day 1;
Day 5.
Onderzoeksproduct en/of interventie
N/A
Publiek
Michelangelolaan 2
Misha Luyer
Eindhoven 5623 EJ
The Netherlands
m.luyer@maastrichtuniversity.nl
Wetenschappelijk
Michelangelolaan 2
Misha Luyer
Eindhoven 5623 EJ
The Netherlands
m.luyer@maastrichtuniversity.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Age ≥ 18 jaar;
2. Suspection of acute mesenteric ischemia;
3. Signed informed consent.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Previous abdominal surgery within 1 week of presentation.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
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Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL2890 |
| NTR-old | NTR3036 |
| Ander register | METC Eindhoven : M11-1125 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |
Samenvatting resultaten
2. Kassahun WT, Schulz T, Richter O, Hauss J. Unchanged high mortality rates from acute occlusive intestinal ischemia: six year review. Langenbecks Arch Surg 2008;393:163-71.PMID 18172675.<br>
3. Sise MJ. Mesenteric ischemia: the whole spectrum. Scand J Surg;99:106-10.PMID 20679047
4. Thuijls G, van Wijck K, Grootjans J, Derikx JP, van Bijnen AA, Heineman E, Dejong CH, Buurman WA, Poeze M. Early diagnosis of intestinal ischemia using urinary and plasma fatty acid binding proteins. Ann Surg;253:303-8.PMID 21245670.<br>
5. Menke J. Diagnostic accuracy of multidetector CT in acute mesenteric ischemia: systematic review and meta-analysis. Radiology;256:93-101.PMID 20574087.<br>
6. Thuijls G, Derikx JP, van Wijck K, Zimmermann LJ, Degraeuwe PL, Mulder TL, Van der Zee DC, Brouwers HA, Verhoeven BH, van Heurn LW, Kramer BW, Buurman WA, Heineman E. Non-invasive markers for early diagnosis and determination of the severity of necrotizing enterocolitis. Ann Surg;251:1174-80.PMID 20485148.