Metabolic effects of deep brain stimulation in patients with obsessive compulsive disorder.

Central regulation of glucose- and lipid metabolism is an area of research in the field of obesity and insulin. Especially the nucleus accumbens has become an area of interest, because of its involvement in food intake, satiety and energy expenditure. It has been shown that dopamine metabolism in the mesoaccumbens system may be altered in obesity with contradictory rsults showing either reduced or increased dopamine signaling. The procedure of DBS in de nucleus accumbens provides an exceptional opportunity to gain insight in the role of the nucleus accumbens in these metabolic processes.

We will perform a hyperinsulinemic euglycemic clamp with stable isotopes in the off and on situation, to measure glucose- and lipid metabolism and use plasma ACTH and urine cortisol levels to measure HPA axis activity.

Deep brain stimulation influences the HPA axis and glucose- and lipid metabolism in patients with obsessive compulsive disorder (OCD).

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Hyperinsulinemic euglycemic clamp with stable isotopes.