To assess the agreement of COqCO with reference CO values in patients under general anaesthesia in whom fluid is administered, as well as to study the influence of fluid administration on the ability of RPVI to reflect preload dependency.
ID
Bron
Verkorte titel
Aandoening
Anesthesiology;thoracic impedance cardiography derived cardiac outpout; pleth variability index
Anesthesie; cardiac output afgeleid van thoracale impedantie cardiografie; pleth variabiliteitsindex
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The main study endpoint is the agreement of COqCO with reference CO in terms of bias, precision and trending ability. The change in RPVI will be assessed with respect to changes in SVV, to evaluate the ability of RPVI to track fluid-induced changes in preload dependency.
Achtergrond van het onderzoek
Technologic advances allow cardiac output (CO) to be monitored completely noninvasively using impendance cardiography (COqCO). Also, cardiac preload dependency can be assessed noninvasively using variations in plethysmography (RPVI). In patients under general anaesthesia in whom fluid is administered, the agreement of COqCO with clinical reference CO values is unknown, as well the ability of RPVI to assess changes in preload dependency.
Doel van het onderzoek
To assess the agreement of COqCO with reference CO values in patients under general anaesthesia in whom fluid is administered, as well as to study the influence of fluid administration on the ability of RPVI to reflect preload dependency.
Onderzoeksopzet
From start of induction of anesthesia until end of surgery.
Onderzoeksproduct en/of interventie
After induction of anaesthesia and once a steady state haemodynamic phase has been reached before incision, all patients will be administered 5ml kg-1 crystalloids i.v. in 5-10 minutes. The haemodynamic response will be evaluated by measuring COqCO, RPVI and the respective reference values, i.e. FloTrac/EV1000 TM derived CO and stroke volume variation (SVV), respectively.
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
• Patients scheduled for elective non-cardiac surgery requiring invasive arterial blood pressure monitoring.
• Patients older than 18.
• ASA physical status I-III.
• Informed and willing to give written informed consent.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
• Patients who refuse to participate.
• Patients unable to consent (i.e. severe mental disorder, younger than 18).
• Patients with pacemakers.
• Patients with severe cardiac pathologies or hemodynamically unstable.
• Patients with end-stage renal failure.
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL6852 |
| NTR-old | NTR7030 |
| Ander register | UMCG Research Register : 201800142 |