* Mortality among adult ischaemic and intra-cerebral haemorrhagic stroke patients admitted to an Intensive care Unit (ICU) is higher compared to other critically ill populations, subdivided into predefined diagnostic groups, over time and regardless…
ID
Bron
Verkorte titel
Aandoening
stroke; ischaemic and intra-cerebral haemorrhagic;
cerebrovascular accident (CVA); critical care; Intensive Care Unit (ICU)
Dutch:
Beroerte; Cerebrovasculair accident (CVA); Intensive Care (IC)
Ondersteuning
* National Intensive Care Evaluation Foundation, Academic Medical Centre, Amsterdam, the Netherlands
* Department of Medical Informatics, Academic Medical Centre, Amsterdam, the Netherlands
* Department of Intensive Care, Leiden University Medical Centre, Leiden, the Netherlands
* Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands
* Department of Anesthesiology, Academic Medical Centre, Amsterdam, the Netherlands
* Revalidatiefonds
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
All-cause mortality after ICU admission
Achtergrond van het onderzoek
The dual aim of the SOPHISTIC project is (1) to assess all-cause mortality over time (both short-term and long-term) of acute intracerebral haemorrhagic and ischaemic adult stroke patients admitted to critical care and compare it to the mortality of other critically ill populations, divided into predefined diagnostic groups, in order to unravel the mortality pattern of stroke patients and (2) to develop a prognostic model of short-term and long-term mortality among stroke patients admitted to critical care, assess the performance of the model and create a practical point system.
Doel van het onderzoek
* Mortality among adult ischaemic and intra-cerebral haemorrhagic stroke patients admitted to an Intensive care Unit (ICU) is higher compared to other critically ill populations, subdivided into predefined diagnostic groups, over time and regardless of case-mix adjustment or left-truncation.
* Short-term mortality and long-term mortality among stroke patients admitted to critical care can be predicted independently by a discriminative and accurate prognostic model based on clinical parameters available upon ICU admission.
Onderzoeksopzet
* Censoring >1year after inclusion time period
* Left-truncation on (A) ICU admission (none), (B) ICU
discharge, (C) after 30 days, (D) 3 months and (E) 1 year.
Onderzoeksproduct en/of interventie
None (observational cohort study)
Publiek
Mariel van Valburg
P.O. Box 85500, Mail stop Q.04.2.313
Utrecht 3508 GA
The Netherlands
m.k.vanvalburg@umcutrecht.nl
Wetenschappelijk
Mariel van Valburg
P.O. Box 85500, Mail stop Q.04.2.313
Utrecht 3508 GA
The Netherlands
m.k.vanvalburg@umcutrecht.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Consecutive adult ischaemic and intra-cerebral haemorrhagic stroke patients admitted to a Dutch ICU assembled to the National Intensive Care Evaluation (NICE) registry
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
* linkage discrepancy between the NICE registry and the Vektis national insurance claim database (impossibility to obtain date of death after ICU admission)
* invalid APACHE III scores
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
Register | ID |
---|---|
NTR-new | NL7239 |
NTR-old | NTR7438 |
Ander register | IRB protocol nummer, METC AMC Amsterdam : W18_049#18.067 |
Samenvatting resultaten
Clinical Predictors of Survival and Functional Outcome of Stroke Patients Admitted to Critical Care. Crit Care Med. 2018 Jul;46(7):1085-1092. <br>
DOI: 10.1097/CCM.0000000000003127. <br>
PubMed PMID: 29608513.<br>
ISRCTN: 13328713.