Maxillary sinus floor augmentation with autogenous bone and bovine bone mineral in the resorbed maxilla: a 1-year multicentre, split-mouth, randomized clinical trial

Insufficient bone height is a common problem in the reconstruction of the edentulous posterior maxilla prior to the placement of dental implants. To create sufficient height, maxillary sinus floor augmentation (MSFA) is performed with autogenous bone (AB) or bone substitutes, such as bovine bone mineral (BBM). AB is considered the golden standard, but has major drawbacks such as fast resorption, limited availability and considerable morbidity at the donor side. BBM might perform better then AB, but there is a lack of randomized controlled trials.



A bilateral MSFA will be performed in 46 patients with a resorbed posterior maxilla. MSFA will be performed randomly with AB harvested from mandibular ramus on one side and with BBM, mixed with some locally harvested AB chips (via existing incision for sinus elevation) on the other side.

Implant placement will be performed 4-6 months after augmentation. Second-phase surgery and implant loading will be performed 4-6 months thereafter.



The aim of this study is to assess the success of MSFA determined by 1-year clinical performance of dental implants placed in augmented maxillary sinus with solely AB versus BBM with some locally harvested AB chips.

The succes of dental implants placed in the augmented maxillary sinus by using a bovine bone mineral (BBM) with some locally harvested AB chips, is superior to, implants placed in augmented sinuses with solely autogenous bone.

Intake, MSFA procedure, check up after two weeks, implant placement procedure, check up after two weeks, second-phase surgery, 1 month after placement of final prosthesis, 1 year after placement of final prosthesis

The study will be designed as a multicenter, split-mouth, randomized split mouth study.: Randomisation will be carried out between two sides:

1. AB harvested from mandibular ramus

2. BBM, Cerabone (Cerabone, Botiss Dental, Berlin, Germany) mixed with approximately one-fifth locally harvested AB chips (via existing incision for sinus elevation).