We expect that tDCS will enhance speed of language recovery, resulting in improved communication, quality of life and participation - associated with decreased rehabilitation consumption and cost reduction.
ID
Bron
Verkorte titel
Aandoening
We will study participants with aphasia, an acquired language disorder caused by stroke.
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De participanten van het onderzoek hebben afasie, een niet-aangeboren taalstoornis die door een beroerte (CVA) is ontstaan.
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
language functioning i.e. word finding (Boston naming test)
Achtergrond van het onderzoek
In summary, we will study whether tDCS has an additional effect in the rehabilitation of aphasia. To investigate this, two groups will be studied: 1 group receives real current stimulation and 1 group receives no current stimulation (sham-tDCS).
The intervention (real tDCS or sham-tDCS)will be added to language therapy sessions. We hypothesise that real tDCS will lead to a significant improvement in language functioning, and that this group difference will also be there at 6 months follow-up.
Doel van het onderzoek
We expect that tDCS will enhance speed of language recovery, resulting in improved communication, quality of life and participation - associated with decreased rehabilitation consumption and cost reduction.
Onderzoeksopzet
5 timepoints for language tests&questionnaires:
- before intervention week 1
- after intervention week 1
- before intervention week 2
- after intervention week 2
- follow-up: 6 months
For the fMRI, there are 2 timepoints:
- before intervention week 1
- after intervention week 2
Onderzoeksproduct en/of interventie
The intervention is tDCS (Transcraniele Direct Current Stimulation). We will study whether tDCS has an additional effect in the rehabilitation of aphasia. To investigate this, two groups will be studied: 1 group receives real current stimulation and 1 group receives no current stimulation (sham-tDCS).
The intervention (real tDCS or sham-tDCS)will be added to language therapy sessions. Two seperate intervention weeks will be planned, in each week the participants will get 5 1-hoursessions of real tDCS or sham-tDCS+language therapy.
Publiek
Westersingel 300
K. Spielmann
Rotterdam
The Netherlands
010 2412412
KSpielmann@rijndam.nl
Wetenschappelijk
Westersingel 300
K. Spielmann
Rotterdam
The Netherlands
010 2412412
KSpielmann@rijndam.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
-Aphasia after stroke
-Time post onset < 3 months
-Age 18-75 years
-Right handed
-Physical health sufficient to participate in intensive aphasia therapy
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
-Subarachnoïd Haemorrhage (SAH)
-Prior stroke resulting in aphasia
-Brain surgery in the past
-Epileptic activity in the past 12 months
-Excessive use of alcohol or drugs
-Insufficient level of Dutch premorbidly
-Premorbid (suspected) dementia
-Premorbid psychiatric disease affecting communication
-Severe non-linguistic cognitive disturbances impeding language therapy
-Pace maker
-Global aphasia (spontaneous speech 0 AND shortened Token Test < 9)
-Severe Wernicke’s aphasia (spontaneous speech 0-1 AND shortened Token Test <9)
-Residual aphasia (spontaneous speech 4-5 AND shortened Token Test > 28 AND Boston Naming Test > 150)
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL4211 |
| NTR-old | NTR4364 |
| Ander register | METC : MEC-2013-147 |