Cognitive rehabilitation and mindfulness in multiple sclerosis

The REMIND-MS study is a dual-centre randomised controlled trail (RCT) that will primarily investigate the effect of cognitive rehabilitation therapy (CRT) and mindfulness-based cognitive therapy (MBCT) on subjectively experienced cognitive problems among MS patients. The study will also investigate the effect of CRT and MBCT on the secondary outcome measures, and we will investigate which factors predict a beneficial effect of the interventions.



Furthermore, resting-state magnetoencephalography (MEG) data will be obtained to gain additional knowledge about the aetiology of subjective and objective cognitive problems with respect to functional brain networks, and to explore the role of functional brain network changes in the effect of the interventions.



In addition, it will be evaluated whether alterations in the secondary outcome measures are mediating factors that determine subjective cognitive function.

We hypothesize that both cognitive rehabilitation therapy (CRT) and mindfulness-based cognitive therapy (MBCT) positively affect the primary outcome measure subjective cognitive function compared to enhanced treatment as usual (ETAU). Secondarily, we expect positive effects on the secondary outcome measures objective cognitive functioning, functional brain network measures, psychological symptoms, well-being, quality of life and daily life functioning. Additionally, we will exploratory evaluate whether there are differences in intervention effects between CRT and MBCT.

Baseline, post-intervention, 6-months follow-up

Cognitive rehabilitation therapy (CRT) and mindfulness-based cognitive therapy (MBCT).



Control condition: enhanced treatment as usual (ETAU).