1. We postulate that an electronic nose can discriminate exhaled breath of patients with ALI/ARDS lung injury from patients without lung injury and without being at risk for developing lung injury 2. We postulate that an electronic nose can…
ID
Bron
Verkorte titel
Aandoening
ALI, ARDS, eNOSE, sepsis, mechanical ventilation.
ALI, ARDS, eNOSE, sepsis, beademing.
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Electronic nose smellprint. <br>
Exhaled air is collected via a connector in the circuit of the mechanical ventilator near the tube and, if present, proximal to the filter. The connector is attached to the electronic nose (Cyranose 320) and measurements are taken for 60 seconds. <br>
When exposed to a gas mixture, the sensors of the electronic nose will swell and thus change the electrical conductance, resulting in a unique smellprint.
Achtergrond van het onderzoek
Critically ill patients may develop acute lung injury (ALI) or its more severe form acute respiratory distress syndrome (ARDS), which can be the result of either a pulmonary insult (e.g., pneumonia) or indirect injury (e.g., sepsis). Early and adequate recognition of ALI/ARDS is mandatory for intensive care physicians to take sufficient actions at the right time. In today’s intensive care practice, ALI/ARDS is diagnosed and monitored by clinical symptoms, radiology findings and laboratory measurements.
However, diagnosing ALI/ARDS remains challenging. Exhaled breath molecular profiling using electronic nose technology can potentially be usefull in diagnosing as well as monitoring lung injury in mechanically ventilated patients.
Doel van het onderzoek
1. We postulate that an electronic nose can discriminate exhaled breath of patients with ALI/ARDS lung injury from patients without lung injury and without being at risk for developing lung injury
2. We postulate that an electronic nose can recognize worsening or improvement of lung injury in patients at risk for ALI/ARDS
3. We postulate that an electronic nose can predict the development of ALI/ARDS in patients at risk for ALI/ARDS
Onderzoeksopzet
The electronic nose will measure the exhaled breath of the included patients once every day.
Onderzoeksproduct en/of interventie
No interventions, diagnostic study.
Publiek
Academic Medical Center (AMC) <br>
University of Amsterdam<br>
Department of Pulmonology <br> F5-260 <br>
P.O.Box 22660
Niki Fens
Meibergdreef 9
1100 DD
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5664359
N.Fens@amc.nl
Wetenschappelijk
Academic Medical Center (AMC) <br>
University of Amsterdam<br>
Department of Pulmonology <br> F5-260 <br>
P.O.Box 22660
Niki Fens
Meibergdreef 9
1100 DD
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5664359
N.Fens@amc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Patients with established ALI/ARDS according to the American/European Consensus Criteria
2. Patients at risk for developing ALI/ARDS
3. Patients without lung injury, not at risk for developing ALI/ARDS and not known to a have pre-existent pulmonary condition
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Younger than 18 years of age
2. Pregnancy
3. Current malignancy
4. Use of steroids in higher than hysiologic dosages (300 mg hydrocortisone or equivalent)
5. Recent cardiopulmonary surgery (reason for admittance)
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL1488 |
| NTR-old | NTR1558 |
| Ander register | METC AMC : AMC20080915.1 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd |