Brown adipose tissue (BAT) is thought to be involved in human glucose and lipid metabolism, however the mechanisms by which this adipose tissue is activated remain to be elucidated. Recent data in db/db mice have suggested that oral butyrate has…
ID
Bron
Verkorte titel
Aandoening
insulin sensitivity; brown adipose tissue;
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Primary objective: To investigate whether butyrate influences the metabolic activity of BAT (as assessed with a FDG-PET CT scan) in relation to hepatic and peripheral insulin sensitivity (two step hyperinsulinemic normoglycemic clamp).
Achtergrond van het onderzoek
We aim to investigate the effect of oral butyrate on insulin sensitivity and brown fat activation in both lean male subjects and obese insulin resistant subjects matched for age.
Doel van het onderzoek
Brown adipose tissue (BAT) is thought to be involved in human glucose and lipid metabolism, however the mechanisms by which this adipose tissue is activated remain to be elucidated. Recent data in db/db mice have suggested that oral butyrate has effect on glucose metabolism and BAT activation. We will now investigate the effect of oral sodium butyrate daily during 4 weeks in both healthy lean and obese, insulin resistant male subjects (matched for age) on insulin sensitivity and BAT activation.
Onderzoeksopzet
0 and 4 weeks
Onderzoeksproduct en/of interventie
Intervention: Patients will be treated with sodiumbutyrate orally once daily during 4 weeks
Publiek
MEIBERGDREEF 9, KAMER F4.159.2
M. Nieuwdorp
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5666612
m.nieuwdorp@amc.uva.nl
Wetenschappelijk
MEIBERGDREEF 9, KAMER F4.159.2
M. Nieuwdorp
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5666612
m.nieuwdorp@amc.uva.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Healthy lean male volunteers (N=10, BMI 19-25 kg/m2) and obese insulin resistant male volunteers (N=10) matched for age will be recruited and tested for BAT activity and insulin sensitivity before and after oral butyrate treatment.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Any Medication or probiotic use
- Smoking
- Participation in a research protocol involving radiation exposure in the last 2 years.
- eGFR <60 ml/min
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL4247 |
| NTR-old | NTR4392 |
| Ander register | : MEC 13/239 |